| http://purl.uniprot.org/citations/24344185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24344185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24344185 | http://www.w3.org/2000/01/rdf-schema#comment | "Remodeling of the extracellular matrix by carcinoma cells during metastatic dissemination requires formation of actin-based protrusions of the plasma membrane called invadopodia, where the trans-membrane type 1 matrix metalloproteinase (MT1-MMP) accumulates. Here, we describe an interaction between the exocyst complex and the endosomal Arp2/3 activator Wiskott-Aldrich syndrome protein and Scar homolog (WASH) on MT1-MMP–containing late endosomes in invasive breast carcinoma cells. We found that WASH and exocyst are required for matrix degradation by an exocytic mechanism that involves tubular connections between MT1-MMP–positive late endosomes and the plasma membrane in contact with the matrix. This ensures focal delivery of MT1-MMP and supports pericellular matrix degradation and tumor cell invasion into different pathologically relevant matrix environments. Our data suggest a general mechanism used by tumor cells to breach the basement membrane and for invasive migration through fibrous collagen-enriched tissues surrounding the tumor."xsd:string |
| http://purl.uniprot.org/citations/24344185 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201306162"xsd:string |
| http://purl.uniprot.org/citations/24344185 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201306162"xsd:string |
| http://purl.uniprot.org/citations/24344185 | http://purl.uniprot.org/core/author | "Formstecher E."xsd:string |
| http://purl.uniprot.org/citations/24344185 | http://purl.uniprot.org/core/author | "Formstecher E."xsd:string |
| http://purl.uniprot.org/citations/24344185 | http://purl.uniprot.org/core/author | "Rosse C."xsd:string |
| http://purl.uniprot.org/citations/24344185 | http://purl.uniprot.org/core/author | "Rosse C."xsd:string |
| http://purl.uniprot.org/citations/24344185 | http://purl.uniprot.org/core/author | "Gautreau A."xsd:string |
| http://purl.uniprot.org/citations/24344185 | http://purl.uniprot.org/core/author | "Gautreau A."xsd:string |
| http://purl.uniprot.org/citations/24344185 | http://purl.uniprot.org/core/author | "Irondelle M."xsd:string |
| http://purl.uniprot.org/citations/24344185 | http://purl.uniprot.org/core/author | "Irondelle M."xsd:string |
| http://purl.uniprot.org/citations/24344185 | http://purl.uniprot.org/core/author | "Castro-Castro A."xsd:string |
| http://purl.uniprot.org/citations/24344185 | http://purl.uniprot.org/core/author | "Castro-Castro A."xsd:string |
| http://purl.uniprot.org/citations/24344185 | http://purl.uniprot.org/core/author | "Chavrier P."xsd:string |
| http://purl.uniprot.org/citations/24344185 | http://purl.uniprot.org/core/author | "Chavrier P."xsd:string |
| http://purl.uniprot.org/citations/24344185 | http://purl.uniprot.org/core/author | "Hertzog M."xsd:string |
| http://purl.uniprot.org/citations/24344185 | http://purl.uniprot.org/core/author | "Hertzog M."xsd:string |
| http://purl.uniprot.org/citations/24344185 | http://purl.uniprot.org/core/author | "Monteiro P."xsd:string |
| http://purl.uniprot.org/citations/24344185 | http://purl.uniprot.org/core/author | "Monteiro P."xsd:string |
| http://purl.uniprot.org/citations/24344185 | http://purl.uniprot.org/core/author | "Darchen F."xsd:string |
| http://purl.uniprot.org/citations/24344185 | http://purl.uniprot.org/core/author | "Darchen F."xsd:string |
| http://purl.uniprot.org/citations/24344185 | http://purl.uniprot.org/core/author | "Desnos C."xsd:string |
| http://purl.uniprot.org/citations/24344185 | http://purl.uniprot.org/core/author | "Desnos C."xsd:string |