| http://purl.uniprot.org/citations/24344271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24344271 | http://www.w3.org/2000/01/rdf-schema#comment | "Disease conditions associated with pulmonary fibrosis are progressive and have a poor long-term prognosis with irreversible changes in airway architecture leading to marked morbidity and mortalities. Using murine models we demonstrate a role for interleukin (IL)-25 in the generation of pulmonary fibrosis. Mechanistically, we identify IL-13 release from type 2 innate lymphoid cells (ILC2) as sufficient to drive collagen deposition in the lungs of challenged mice and suggest this as a potential mechanism through which IL-25 is acting. Additionally, we demonstrate that in human idiopathic pulmonary fibrosis there is increased pulmonary expression of IL-25 and also observe a population ILC2 in the lungs of idiopathic pulmonary fibrosis patients. Collectively, we present an innate mechanism for the generation of pulmonary fibrosis, via IL-25 and ILC2, that occurs independently of T-cell-mediated antigen-specific immune responses. These results suggest the potential of therapeutically targeting IL-25 and ILC2 for the treatment of human fibrotic diseases."xsd:string |
| http://purl.uniprot.org/citations/24344271 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1315854111"xsd:string |
| http://purl.uniprot.org/citations/24344271 | http://purl.uniprot.org/core/author | "Schwartz C."xsd:string |
| http://purl.uniprot.org/citations/24344271 | http://purl.uniprot.org/core/author | "Crotty T.B."xsd:string |
| http://purl.uniprot.org/citations/24344271 | http://purl.uniprot.org/core/author | "Cooke G."xsd:string |
| http://purl.uniprot.org/citations/24344271 | http://purl.uniprot.org/core/author | "McKenzie A.N."xsd:string |
| http://purl.uniprot.org/citations/24344271 | http://purl.uniprot.org/core/author | "Voehringer D."xsd:string |
| http://purl.uniprot.org/citations/24344271 | http://purl.uniprot.org/core/author | "Armstrong M.E."xsd:string |
| http://purl.uniprot.org/citations/24344271 | http://purl.uniprot.org/core/author | "Fallon P.G."xsd:string |
| http://purl.uniprot.org/citations/24344271 | http://purl.uniprot.org/core/author | "Hams E."xsd:string |
| http://purl.uniprot.org/citations/24344271 | http://purl.uniprot.org/core/author | "Saunders S.P."xsd:string |
| http://purl.uniprot.org/citations/24344271 | http://purl.uniprot.org/core/author | "Hirani N."xsd:string |
| http://purl.uniprot.org/citations/24344271 | http://purl.uniprot.org/core/author | "Donnelly S.C."xsd:string |
| http://purl.uniprot.org/citations/24344271 | http://purl.uniprot.org/core/author | "Fahy R.J."xsd:string |
| http://purl.uniprot.org/citations/24344271 | http://purl.uniprot.org/core/author | "Barlow J.L."xsd:string |
| http://purl.uniprot.org/citations/24344271 | http://purl.uniprot.org/core/author | "Flynn R.J."xsd:string |
| http://purl.uniprot.org/citations/24344271 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24344271 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/24344271 | http://purl.uniprot.org/core/pages | "367-372"xsd:string |
| http://purl.uniprot.org/citations/24344271 | http://purl.uniprot.org/core/title | "IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis."xsd:string |
| http://purl.uniprot.org/citations/24344271 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/24344271 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24344271 |
| http://purl.uniprot.org/citations/24344271 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24344271 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGP1-mappedCitation-24344271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24344271 |