| http://purl.uniprot.org/citations/24345480 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24345480 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNAs (miRNAs) function as key regulators of gene expression in various cancers. In this study, the aim is to explore the roles and regulation mechanism of miR-181c in neuroblastoma (NB) cells. We found that miR-181c was downregulated in metastatic NB tissues, compared with primary NB tissues. Then functional studies indicated that miR-181c overexpression inhibited NB cell proliferation, migration, and invasion, while miR-181c inhibition increased cell proliferation, migration, and invasion. EGFP reporter assay, real-time polymerase chain reaction and western blot analysis validated that Smad7 was a direct target of miR-181c. MiR-181c reduced Smad7 expression at both mRNA and protein levels. Finally, functional assays showed that the effect of Smad7 knockdown on cells was similar to that of miR-181c overexpression. Importantly, Smad7 overexpression could restore the antitumor effects that were induced by miR-181c. In conclusion, our results demonstrated that miR-181c inhibits NB cell growth and metastasis-related traits through the suppression of Smad7, functioning as a tumor suppressor. Moreover, our results suggested that miR-181c may serve as an important therapeutic target for NB patients."xsd:string |
| http://purl.uniprot.org/citations/24345480 | http://purl.org/dc/terms/identifier | "doi:10.1093/abbs/gmt124"xsd:string |
| http://purl.uniprot.org/citations/24345480 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/24345480 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/24345480 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/24345480 | http://purl.uniprot.org/core/author | "Yue W."xsd:string |
| http://purl.uniprot.org/citations/24345480 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24345480 | http://purl.uniprot.org/core/name | "Acta Biochim Biophys Sin (Shanghai)"xsd:string |
| http://purl.uniprot.org/citations/24345480 | http://purl.uniprot.org/core/pages | "48-55"xsd:string |
| http://purl.uniprot.org/citations/24345480 | http://purl.uniprot.org/core/title | "MiR-181c modulates the proliferation, migration, and invasion of neuroblastoma cells by targeting Smad7."xsd:string |
| http://purl.uniprot.org/citations/24345480 | http://purl.uniprot.org/core/volume | "46"xsd:string |
| http://purl.uniprot.org/citations/24345480 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24345480 |
| http://purl.uniprot.org/citations/24345480 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24345480 |
| http://purl.uniprot.org/uniprot/#_B3KYA8-mappedCitation-24345480 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24345480 |
| http://purl.uniprot.org/uniprot/#_O15105-mappedCitation-24345480 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24345480 |
| http://purl.uniprot.org/uniprot/B3KYA8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24345480 |
| http://purl.uniprot.org/uniprot/O15105 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24345480 |