| http://purl.uniprot.org/citations/24347622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24347622 | http://www.w3.org/2000/01/rdf-schema#comment | "Screening for suppressor mutations is a powerful method to isolate genes that function in a common pathway or process. Because suppressor mutations often do not have phenotypes on their own, cloning of suppressor loci can be challenging. A method combining whole-genome sequencing (WGS) and single nucleotide polymorphism (SNP) mapping (WGS/SNP mapping) was developed to identify mutations with visible phenotypes in C. elegans. We show here that WGS/SNP mapping is an efficient method to map suppressor mutations without the need for previous phenotypic characterization. Using RNA-mediated interference to test candidate loci identified by WGS/SNP mapping, we identified 10 extragenic and six intragenic suppressors of mbk-2, a DYRK family kinase required for the transition from oocyte to zygote. Remarkably, seven suppressors are mutations in cell-cycle regulators that extend the timing of the oocyte-to-zygote transition."xsd:string |
| http://purl.uniprot.org/citations/24347622 | http://purl.org/dc/terms/identifier | "doi:10.1534/g3.113.009126"xsd:string |
| http://purl.uniprot.org/citations/24347622 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/24347622 | http://purl.uniprot.org/core/author | "Rasoloson D."xsd:string |
| http://purl.uniprot.org/citations/24347622 | http://purl.uniprot.org/core/author | "Seydoux G."xsd:string |
| http://purl.uniprot.org/citations/24347622 | http://purl.uniprot.org/core/author | "Wang J.T."xsd:string |
| http://purl.uniprot.org/citations/24347622 | http://purl.uniprot.org/core/author | "Smith H.E."xsd:string |
| http://purl.uniprot.org/citations/24347622 | http://purl.uniprot.org/core/author | "Stitzel M.L."xsd:string |
| http://purl.uniprot.org/citations/24347622 | http://purl.uniprot.org/core/author | "O' Connell K.F."xsd:string |
| http://purl.uniprot.org/citations/24347622 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24347622 | http://purl.uniprot.org/core/name | "G3 (Bethesda)"xsd:string |
| http://purl.uniprot.org/citations/24347622 | http://purl.uniprot.org/core/pages | "231-241"xsd:string |
| http://purl.uniprot.org/citations/24347622 | http://purl.uniprot.org/core/title | "Identification of suppressors of mbk-2/DYRK by whole-genome sequencing."xsd:string |
| http://purl.uniprot.org/citations/24347622 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/24347622 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24347622 |
| http://purl.uniprot.org/citations/24347622 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24347622 |
| http://purl.uniprot.org/uniprot/#_A0A061ACK4-mappedCitation-24347622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24347622 |
| http://purl.uniprot.org/uniprot/#_A0A061ACN3-mappedCitation-24347622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24347622 |
| http://purl.uniprot.org/uniprot/#_A0A061ACN7-mappedCitation-24347622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24347622 |
| http://purl.uniprot.org/uniprot/#_A0A061ADU8-mappedCitation-24347622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24347622 |
| http://purl.uniprot.org/uniprot/#_A0A061AJ20-mappedCitation-24347622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24347622 |
| http://purl.uniprot.org/uniprot/#_A0A061AKR6-mappedCitation-24347622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24347622 |
| http://purl.uniprot.org/uniprot/#_P34331-mappedCitation-24347622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24347622 |
| http://purl.uniprot.org/uniprot/#_P34441-mappedCitation-24347622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24347622 |