| http://purl.uniprot.org/citations/24349371 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24349371 | http://www.w3.org/2000/01/rdf-schema#comment | "Herein we demonstrate with PCR, immunodetection and reporter gene approaches that the widely used human Glial Fibrillary Acidic Protein (hGFAP)-Cre transgene exhibits spontaneous germ-line recombination activity in leading to deletion in brain, heart and tail tissue with high frequency. The ectopic activity of hGFAP-Cre requires a rigorous control. We likewise observed that a second widely used nestin-Cre transgene shows germ-line deletion. Here we describe procedures to identify mice with germ-line recombination mediated by the hGFAP-Cre and nestin-Cre transgenes. Such control is essential to avoid pleiotropic effects due to germ-line deletion of loxP-flanked target genes and to maintain the CNS-restricted deletion status in transgenic mouse colonies."xsd:string |
| http://purl.uniprot.org/citations/24349371 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0082818"xsd:string |
| http://purl.uniprot.org/citations/24349371 | http://purl.uniprot.org/core/author | "Klein A."xsd:string |
| http://purl.uniprot.org/citations/24349371 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/24349371 | http://purl.uniprot.org/core/author | "Theis M."xsd:string |
| http://purl.uniprot.org/citations/24349371 | http://purl.uniprot.org/core/author | "Steinhauser C."xsd:string |
| http://purl.uniprot.org/citations/24349371 | http://purl.uniprot.org/core/author | "Fleischmann B.K."xsd:string |
| http://purl.uniprot.org/citations/24349371 | http://purl.uniprot.org/core/author | "Brehm R."xsd:string |
| http://purl.uniprot.org/citations/24349371 | http://purl.uniprot.org/core/author | "Bedner P."xsd:string |
| http://purl.uniprot.org/citations/24349371 | http://purl.uniprot.org/core/author | "Dublin P."xsd:string |
| http://purl.uniprot.org/citations/24349371 | http://purl.uniprot.org/core/author | "Griemsmann S."xsd:string |
| http://purl.uniprot.org/citations/24349371 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24349371 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/24349371 | http://purl.uniprot.org/core/pages | "e82818"xsd:string |
| http://purl.uniprot.org/citations/24349371 | http://purl.uniprot.org/core/title | "Germ-line recombination activity of the widely used hGFAP-Cre and nestin-Cre transgenes."xsd:string |
| http://purl.uniprot.org/citations/24349371 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/24349371 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24349371 |
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| http://purl.uniprot.org/uniprot/#_A0A1W2P793-mappedCitation-24349371 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24349371 |
| http://purl.uniprot.org/uniprot/#_A0A654ICD2-mappedCitation-24349371 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24349371 |
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| http://purl.uniprot.org/uniprot/#_P23242-mappedCitation-24349371 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24349371 |