| http://purl.uniprot.org/citations/24349374 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24349374 | http://www.w3.org/2000/01/rdf-schema#comment | "Mipu1 (myocardial ischemic preconditioning up-regulated protein 1), recently identified in our lab, is a novel zinc-finger transcription factor which is up-regulated during ischemic preconditioning. However, it is not clear what transcription factor contributes to its inducible expression. In the present study, we reported that HIF-1 regulates the inducible expression of Mipu1 which is involved in the cytoprotection of HIF-1α against oxidative stress by inhibiting Bax expression. Our results showed that the inducible expression of Mipu1 was associated with the expression and activation of transcription factor HIF-1 as indicated by cobalt chloride (CoCl2) treatment, HIF-1α overexpression and knockdown assays. EMSA and luciferase reporter gene assays showed that HIF-1α bound to the hypoxia response element (HRE) within Mipu1 promoter region and promoted its transcription. Moreover, our results revealed that Mipu1 inhibited the expression of Bax, an important pro-apoptosis protein associated with the intrinsic pathway of apoptosis, elevating the cytoprotection of HIF-1 against hydrogen peroxide (H2O2)-mediated injury in H9C2 cells. Our findings implied that Bax may be a potential target gene of transcription factor Mipu1, and provided a novel insight for understanding the cytoprotection of HIF-1 and new clues for further elucidating the mechanisms by which Mipu1 protects cell against pathological stress."xsd:string |
| http://purl.uniprot.org/citations/24349374 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0082827"xsd:string |
| http://purl.uniprot.org/citations/24349374 | http://purl.uniprot.org/core/author | "Chen A."xsd:string |
| http://purl.uniprot.org/citations/24349374 | http://purl.uniprot.org/core/author | "Jiang L."xsd:string |
| http://purl.uniprot.org/citations/24349374 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/24349374 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/24349374 | http://purl.uniprot.org/core/author | "Xiao X."xsd:string |
| http://purl.uniprot.org/citations/24349374 | http://purl.uniprot.org/core/author | "Wang K."xsd:string |
| http://purl.uniprot.org/citations/24349374 | http://purl.uniprot.org/core/author | "Xiao Z."xsd:string |
| http://purl.uniprot.org/citations/24349374 | http://purl.uniprot.org/core/author | "Zou J."xsd:string |
| http://purl.uniprot.org/citations/24349374 | http://purl.uniprot.org/core/author | "Lei J."xsd:string |
| http://purl.uniprot.org/citations/24349374 | http://purl.uniprot.org/core/author | "Xiao H."xsd:string |
| http://purl.uniprot.org/citations/24349374 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24349374 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/24349374 | http://purl.uniprot.org/core/pages | "e82827"xsd:string |
| http://purl.uniprot.org/citations/24349374 | http://purl.uniprot.org/core/title | "Mipu1, a novel direct target gene, is involved in hypoxia inducible factor 1-mediated cytoprotection."xsd:string |
| http://purl.uniprot.org/citations/24349374 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/24349374 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24349374 |
| http://purl.uniprot.org/citations/24349374 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24349374 |
| http://purl.uniprot.org/uniprot/#_D0VY79-mappedCitation-24349374 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24349374 |
| http://purl.uniprot.org/uniprot/#_B2R617-mappedCitation-24349374 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24349374 |
| http://purl.uniprot.org/uniprot/#_A8MYV6-mappedCitation-24349374 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24349374 |
| http://purl.uniprot.org/uniprot/#_B4E2K5-mappedCitation-24349374 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24349374 |
| http://purl.uniprot.org/uniprot/#_B4E2U7-mappedCitation-24349374 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24349374 |