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http://purl.uniprot.org/citations/24351517http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24351517http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To estimate the prevalence of spondyloarthritis (SpA) in reference to HLA-B27 in the French population.

Methods

In 1989, 20 625 employees of the French national gas and electricity company aged 35-50 years were enrolled in the GAZEL cohort. In 2010, 18 757 still active participants were screened by a questionnaire validated for the detection of SpA. Responders with available DNA were retained for further studies. Pelvic radiograph and HLA-B27 typing were performed in all the self-reported cases of SpA or psoriatic arthritis. Self-reported diagnosis was verified by a qualified rheumatologist. HLA-B27 determination was also performed in subjects without any SpA feature.

Results

The target population consisted of 6556 responders with available DNA. Their male:female ratio was 3.6 and their mean age was 65.5±3.3 years. A diagnosis of SpA was confirmed in 32 of the 72 self-reported cases, 75% of them being HLA-B27 positive. Estimated SpA prevalence adjusted for sex was 0.43% (95% CI 0.26% to 0.70%). HLA-B27 positivity rate in 2466 healthy controls was 6.9% (95% CI 5.9% to 7.9%). The relative risk of SpA in HLA-B27 positive individuals was 39 (95% CI 17 to 86).

Conclusions

We estimated the prevalence of SpA in the French population in 2010 to 0.43%. With an estimated prevalence of 75.0% in SpA and 6.9% in healthy controls, HLA-B27 increased the disease risk 39-fold, as compared with HLA-B27 negative subjects."xsd:string
http://purl.uniprot.org/citations/24351517http://purl.org/dc/terms/identifier"doi:10.1136/annrheumdis-2013-204436"xsd:string
http://purl.uniprot.org/citations/24351517http://purl.uniprot.org/core/author"Goldberg M."xsd:string
http://purl.uniprot.org/citations/24351517http://purl.uniprot.org/core/author"Garchon H.J."xsd:string
http://purl.uniprot.org/citations/24351517http://purl.uniprot.org/core/author"Chiocchia G."xsd:string
http://purl.uniprot.org/citations/24351517http://purl.uniprot.org/core/author"Breban M."xsd:string
http://purl.uniprot.org/citations/24351517http://purl.uniprot.org/core/author"Said-Nahal R."xsd:string
http://purl.uniprot.org/citations/24351517http://purl.uniprot.org/core/author"Costantino F."xsd:string
http://purl.uniprot.org/citations/24351517http://purl.uniprot.org/core/author"Henny J."xsd:string
http://purl.uniprot.org/citations/24351517http://purl.uniprot.org/core/author"Talpin A."xsd:string
http://purl.uniprot.org/citations/24351517http://purl.uniprot.org/core/author"Zins M."xsd:string
http://purl.uniprot.org/citations/24351517http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/24351517http://purl.uniprot.org/core/name"Ann Rheum Dis"xsd:string
http://purl.uniprot.org/citations/24351517http://purl.uniprot.org/core/pages"689-693"xsd:string
http://purl.uniprot.org/citations/24351517http://purl.uniprot.org/core/title"Prevalence of spondyloarthritis in reference to HLA-B27 in the French population: results of the GAZEL cohort."xsd:string
http://purl.uniprot.org/citations/24351517http://purl.uniprot.org/core/volume"74"xsd:string
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