| http://purl.uniprot.org/citations/24351972 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24351972 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24351972 | http://www.w3.org/2000/01/rdf-schema#comment | "Orai1 calcium channels in the plasma membrane are activated by stromal interaction molecule-1 (STIM1), an endoplasmic reticulum calcium sensor, to mediate store-operated calcium entry (SOCE). The cytosolic region of STIM1 contains a long putative coiled-coil (CC)1 segment and shorter CC2 and CC3 domains. Here we present solution nuclear magnetic resonance structures of a trypsin-resistant CC1-CC2 fragment in the apo and Orai1-bound states. Each CC1-CC2 subunit forms a U-shaped structure that homodimerizes through antiparallel interactions between equivalent α-helices. The CC2:CC2' helix pair clamps two identical acidic Orai1 C-terminal helices at opposite ends of a hydrophobic/basic STIM-Orai association pocket. STIM1 mutants disrupting CC1:CC1' interactions attenuate, while variants promoting CC1 stability spontaneously activate Orai1 currents. CC2 mutations cause remarkable variability in Orai1 activation because of a dual function in binding Orai1 and autoinhibiting STIM1 oligomerization via interactions with CC3. We conclude that SOCE is activated through dynamic interplay between STIM1 and Orai1 helices."xsd:string |
| http://purl.uniprot.org/citations/24351972 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms3963"xsd:string |
| http://purl.uniprot.org/citations/24351972 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms3963"xsd:string |
| http://purl.uniprot.org/citations/24351972 | http://purl.uniprot.org/core/author | "Zheng L."xsd:string |
| http://purl.uniprot.org/citations/24351972 | http://purl.uniprot.org/core/author | "Zheng L."xsd:string |
| http://purl.uniprot.org/citations/24351972 | http://purl.uniprot.org/core/author | "Ikura M."xsd:string |
| http://purl.uniprot.org/citations/24351972 | http://purl.uniprot.org/core/author | "Ikura M."xsd:string |
| http://purl.uniprot.org/citations/24351972 | http://purl.uniprot.org/core/author | "Gasmi-Seabrook G.M."xsd:string |
| http://purl.uniprot.org/citations/24351972 | http://purl.uniprot.org/core/author | "Gasmi-Seabrook G.M."xsd:string |
| http://purl.uniprot.org/citations/24351972 | http://purl.uniprot.org/core/author | "Romanin C."xsd:string |
| http://purl.uniprot.org/citations/24351972 | http://purl.uniprot.org/core/author | "Romanin C."xsd:string |
| http://purl.uniprot.org/citations/24351972 | http://purl.uniprot.org/core/author | "Schindl R."xsd:string |
| http://purl.uniprot.org/citations/24351972 | http://purl.uniprot.org/core/author | "Schindl R."xsd:string |
| http://purl.uniprot.org/citations/24351972 | http://purl.uniprot.org/core/author | "Fahrner M."xsd:string |
| http://purl.uniprot.org/citations/24351972 | http://purl.uniprot.org/core/author | "Fahrner M."xsd:string |
| http://purl.uniprot.org/citations/24351972 | http://purl.uniprot.org/core/author | "Muik M."xsd:string |
| http://purl.uniprot.org/citations/24351972 | http://purl.uniprot.org/core/author | "Muik M."xsd:string |
| http://purl.uniprot.org/citations/24351972 | http://purl.uniprot.org/core/author | "Stathopulos P.B."xsd:string |
| http://purl.uniprot.org/citations/24351972 | http://purl.uniprot.org/core/author | "Stathopulos P.B."xsd:string |
| http://purl.uniprot.org/citations/24351972 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24351972 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24351972 | http://purl.uniprot.org/core/name | "Nat. Commun."xsd:string |
| http://purl.uniprot.org/citations/24351972 | http://purl.uniprot.org/core/name | "Nat. Commun."xsd:string |