| http://purl.uniprot.org/citations/24352421 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24352421 | http://www.w3.org/2000/01/rdf-schema#comment | "The self-renewal versus differentiation choice of Drosophila and mammalian neural stem cells (NSCs) requires Notch (N) signaling. How N regulates NSC behavior is not well understood. Here we show that canonical N signaling cooperates with a noncanonical N signaling pathway to mediate N-directed NSC regulation. In the noncanonical pathway, N interacts with PTEN-induced kinase 1 (PINK1) to influence mitochondrial function, activating mechanistic target of rapamycin complex 2 (mTORC2)/AKT signaling. Importantly, attenuating noncanonical N signaling preferentially impaired the maintenance of Drosophila and human cancer stem cell-like tumor-forming cells. Our results emphasize the importance of mitochondria to N and NSC biology, with important implications for diseases associated with aberrant N signaling."xsd:string |
| http://purl.uniprot.org/citations/24352421 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.225169.113"xsd:string |
| http://purl.uniprot.org/citations/24352421 | http://purl.uniprot.org/core/author | "Lee K.S."xsd:string |
| http://purl.uniprot.org/citations/24352421 | http://purl.uniprot.org/core/author | "Song Y."xsd:string |
| http://purl.uniprot.org/citations/24352421 | http://purl.uniprot.org/core/author | "Wu Z."xsd:string |
| http://purl.uniprot.org/citations/24352421 | http://purl.uniprot.org/core/author | "Lu B."xsd:string |
| http://purl.uniprot.org/citations/24352421 | http://purl.uniprot.org/core/author | "Cheshier S.H."xsd:string |
| http://purl.uniprot.org/citations/24352421 | http://purl.uniprot.org/core/author | "Mitra S.S."xsd:string |
| http://purl.uniprot.org/citations/24352421 | http://purl.uniprot.org/core/author | "Feroze A.H."xsd:string |
| http://purl.uniprot.org/citations/24352421 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24352421 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/24352421 | http://purl.uniprot.org/core/pages | "2642-2647"xsd:string |
| http://purl.uniprot.org/citations/24352421 | http://purl.uniprot.org/core/title | "Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/24352421 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/24352421 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24352421 |
| http://purl.uniprot.org/citations/24352421 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24352421 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6Q6-mappedCitation-24352421 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24352421 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LIA3-mappedCitation-24352421 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24352421 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K630-mappedCitation-24352421 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24352421 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LGE6-mappedCitation-24352421 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24352421 |
| http://purl.uniprot.org/uniprot/#_A4V449-mappedCitation-24352421 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24352421 |
| http://purl.uniprot.org/uniprot/#_P21519-mappedCitation-24352421 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24352421 |
| http://purl.uniprot.org/uniprot/#_P28159-mappedCitation-24352421 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24352421 |
| http://purl.uniprot.org/uniprot/#_M9NE67-mappedCitation-24352421 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24352421 |