| http://purl.uniprot.org/citations/24357318 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24357318 | http://www.w3.org/2000/01/rdf-schema#comment | "The inbred mouse C57BL/6J is the reference strain for genome sequence and for most behavioral and physiological phenotypes. However, the International Knockout Mouse Consortium uses an embryonic stem cell line derived from a related C57BL/6N substrain. We found that C57BL/6N has a lower acute and sensitized response to cocaine and methamphetamine. We mapped a single causative locus and identified a nonsynonymous mutation of serine to phenylalanine (S968F) in Cytoplasmic FMRP interacting protein 2 (Cyfip2) as the causative variant. The S968F mutation destabilizes CYFIP2, and deletion of the C57BL/6N mutant allele leads to acute and sensitized cocaine-response phenotypes. We propose that CYFIP2 is a key regulator of cocaine response in mammals and present a framework to use mouse substrains to identify previously unknown genes and alleles regulating behavior."xsd:string |
| http://purl.uniprot.org/citations/24357318 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1245503"xsd:string |
| http://purl.uniprot.org/citations/24357318 | http://purl.uniprot.org/core/author | "Kim K."xsd:string |
| http://purl.uniprot.org/citations/24357318 | http://purl.uniprot.org/core/author | "Bonci A."xsd:string |
| http://purl.uniprot.org/citations/24357318 | http://purl.uniprot.org/core/author | "Joseph C."xsd:string |
| http://purl.uniprot.org/citations/24357318 | http://purl.uniprot.org/core/author | "Kumar V."xsd:string |
| http://purl.uniprot.org/citations/24357318 | http://purl.uniprot.org/core/author | "Huang H.C."xsd:string |
| http://purl.uniprot.org/citations/24357318 | http://purl.uniprot.org/core/author | "Yoo S.H."xsd:string |
| http://purl.uniprot.org/citations/24357318 | http://purl.uniprot.org/core/author | "Takahashi J.S."xsd:string |
| http://purl.uniprot.org/citations/24357318 | http://purl.uniprot.org/core/author | "Vitaterna M.H."xsd:string |
| http://purl.uniprot.org/citations/24357318 | http://purl.uniprot.org/core/author | "Kourrich S."xsd:string |
| http://purl.uniprot.org/citations/24357318 | http://purl.uniprot.org/core/author | "Churchill G."xsd:string |
| http://purl.uniprot.org/citations/24357318 | http://purl.uniprot.org/core/author | "de Villena F.P."xsd:string |
| http://purl.uniprot.org/citations/24357318 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24357318 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/24357318 | http://purl.uniprot.org/core/pages | "1508-1512"xsd:string |
| http://purl.uniprot.org/citations/24357318 | http://purl.uniprot.org/core/title | "C57BL/6N mutation in cytoplasmic FMRP interacting protein 2 regulates cocaine response."xsd:string |
| http://purl.uniprot.org/citations/24357318 | http://purl.uniprot.org/core/volume | "342"xsd:string |
| http://purl.uniprot.org/citations/24357318 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24357318 |
| http://purl.uniprot.org/citations/24357318 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24357318 |
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| http://purl.uniprot.org/uniprot/#_G3UZI5-mappedCitation-24357318 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24357318 |