| http://purl.uniprot.org/citations/24357723 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24357723 | http://www.w3.org/2000/01/rdf-schema#comment | "Sharp-1 is a basic helix-loop-helix (bHLH) transcriptional repressor that is involved in a number of cellular processes. Our previous studies have demonstrated that Sharp-1 is a negative regulator of skeletal myogenesis and it blocks differentiation of muscle precursor cells by modulating the activity of MyoD. In order to understand its role in pre- and post-natal myogenesis, we assessed skeletal muscle development and freeze-injury-induced regeneration in Sharp-1-deficient mice. We show that embryonic skeletal muscle development is not impaired in the absence of Sharp-1; however, post-natally, the regenerative capacity is compromised. Although the initial phases of injury-induced regeneration proceed normally in Sharp-1(-/-) mice, during late stages, the mutant muscle exhibits necrotic fibers, calcium deposits and fibrosis. TGF-β expression, as well as levels of phosphorylated Smad2 and Smad3, are sustained in the mutant tissue and treatment with decorin, which blocks TGF-β signaling, improves the histopathology of Sharp-1(-/-) injured muscles. In vitro, Sharp-1 associates with Smad3, and its overexpression inhibits TGF-β- and Smad3-mediated expression of extracellular matrix genes in myofibroblasts. These results demonstrate that Sharp-1 regulates muscle regenerative capacity, at least in part, by modulation of TGF-β signaling."xsd:string |
| http://purl.uniprot.org/citations/24357723 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.136648"xsd:string |
| http://purl.uniprot.org/citations/24357723 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/24357723 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/24357723 | http://purl.uniprot.org/core/author | "Taneja R."xsd:string |
| http://purl.uniprot.org/citations/24357723 | http://purl.uniprot.org/core/author | "Rossner M."xsd:string |
| http://purl.uniprot.org/citations/24357723 | http://purl.uniprot.org/core/author | "Vercherat C."xsd:string |
| http://purl.uniprot.org/citations/24357723 | http://purl.uniprot.org/core/author | "Chung T.K."xsd:string |
| http://purl.uniprot.org/citations/24357723 | http://purl.uniprot.org/core/author | "Gopinadhan S."xsd:string |
| http://purl.uniprot.org/citations/24357723 | http://purl.uniprot.org/core/author | "Acharjee S."xsd:string |
| http://purl.uniprot.org/citations/24357723 | http://purl.uniprot.org/core/author | "Gulbagci N.T."xsd:string |
| http://purl.uniprot.org/citations/24357723 | http://purl.uniprot.org/core/author | "Shankar S.R."xsd:string |
| http://purl.uniprot.org/citations/24357723 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24357723 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/24357723 | http://purl.uniprot.org/core/pages | "599-608"xsd:string |
| http://purl.uniprot.org/citations/24357723 | http://purl.uniprot.org/core/title | "Sharp-1 regulates TGF-beta signaling and skeletal muscle regeneration."xsd:string |
| http://purl.uniprot.org/citations/24357723 | http://purl.uniprot.org/core/volume | "127"xsd:string |
| http://purl.uniprot.org/citations/24357723 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24357723 |
| http://purl.uniprot.org/citations/24357723 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24357723 |
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| http://purl.uniprot.org/uniprot/#_P04202-mappedCitation-24357723 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24357723 |
| http://purl.uniprot.org/uniprot/#_P10085-mappedCitation-24357723 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24357723 |
| http://purl.uniprot.org/uniprot/#_P12979-mappedCitation-24357723 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24357723 |