| http://purl.uniprot.org/citations/24361048 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24361048 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24361048 | http://www.w3.org/2000/01/rdf-schema#comment | "The tripeptide chains of the ergopeptines, a class of pharmacologically important D-lysergic acid alkaloid peptides, are arranged in a unique bicyclic cyclol based on an amino-terminal α-hydroxyamino acid and a terminal orthostructure. D-lysergyl-tripeptides are assembled by the nonribosomal peptide synthetases LPS1 and LPS2 of the ergot fungus Claviceps purpurea and released as N-(D-lysergyl-aminoacyl)-lactams. We show total enzymatic synthesis of ergopeptines catalyzed by a Fe²⁺/2-ketoglutarate-dependent dioxygenase (EasH) in conjunction with LPS1/LPS2. Analysis of the reaction indicated that EasH introduces a hydroxyl group into N-(D-lysergyl-aminoacyl)-lactam at α-C of the aminoacyl residue followed by spontaneous condensation with the terminal lactam carbonyl group. Sequence analysis revealed that EasH belongs to the wide and diverse family of the phytanoyl coenzyme A hydroxylases. We provide a high-resolution crystal structure of EasH that is most similar to that of phytanoyl coenzyme A hydroxylase, PhyH, from human."xsd:string |
| http://purl.uniprot.org/citations/24361048 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chembiol.2013.11.008"xsd:string |
| http://purl.uniprot.org/citations/24361048 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chembiol.2013.11.008"xsd:string |
| http://purl.uniprot.org/citations/24361048 | http://purl.uniprot.org/core/author | "Keller U."xsd:string |
| http://purl.uniprot.org/citations/24361048 | http://purl.uniprot.org/core/author | "Keller U."xsd:string |
| http://purl.uniprot.org/citations/24361048 | http://purl.uniprot.org/core/author | "Vogel D."xsd:string |
| http://purl.uniprot.org/citations/24361048 | http://purl.uniprot.org/core/author | "Vogel D."xsd:string |
| http://purl.uniprot.org/citations/24361048 | http://purl.uniprot.org/core/author | "Loll B."xsd:string |
| http://purl.uniprot.org/citations/24361048 | http://purl.uniprot.org/core/author | "Loll B."xsd:string |
| http://purl.uniprot.org/citations/24361048 | http://purl.uniprot.org/core/author | "Havemann J."xsd:string |
| http://purl.uniprot.org/citations/24361048 | http://purl.uniprot.org/core/author | "Havemann J."xsd:string |
| http://purl.uniprot.org/citations/24361048 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24361048 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24361048 | http://purl.uniprot.org/core/name | "Chem. Biol."xsd:string |
| http://purl.uniprot.org/citations/24361048 | http://purl.uniprot.org/core/name | "Chem. Biol."xsd:string |
| http://purl.uniprot.org/citations/24361048 | http://purl.uniprot.org/core/pages | "146-155"xsd:string |
| http://purl.uniprot.org/citations/24361048 | http://purl.uniprot.org/core/pages | "146-155"xsd:string |
| http://purl.uniprot.org/citations/24361048 | http://purl.uniprot.org/core/title | "Cyclolization of D-lysergic acid alkaloid peptides."xsd:string |
| http://purl.uniprot.org/citations/24361048 | http://purl.uniprot.org/core/title | "Cyclolization of D-lysergic acid alkaloid peptides."xsd:string |
| http://purl.uniprot.org/citations/24361048 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/24361048 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/24361048 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24361048 |
| http://purl.uniprot.org/citations/24361048 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24361048 |