| http://purl.uniprot.org/citations/24365237 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24365237 | http://www.w3.org/2000/01/rdf-schema#comment | "Little is known about ghrelin's effects on intestinal epithelial cells even though it is known to be a mitogen for a variety of other cell types. Because ghrelin is released in close proximity to the proliferative compartment of the intestinal tract, we hypothesized that ghrelin may have potent pro-proliferative effect on intestinal epithelial cells as well. To test this hypothesis, we characterized the effects of ghrelin on FHs74Int and Caco-2 intestinal epithelial cell lines in vitro. We found that ghrelin has potent dose dependent proliferative effects in both cell lines through a yet to be characterized G protein coupled growth hormone secretagogue receptor (GHS-R) subtype. Consistent with above findings, cell cycle flowcytometric analyses demonstrated that ghrelin shifts cells from the G1 to S phase and thereby promotes cell cycle progression. Further characterization of subcellular events, suggested that ghrelin mediates its pro-proliferative effect through Adenylate cyclase (AC)-independent epidermal growth factor receptor (EGFR) trans-activation and PI3K-Akt phosphorylation. Both these pathways converge to stimulate MAPK, ERK 1/2 downstream. The role of ghrelin in states where intestinal mucosal injury and rapid mucosal repair occur warrants further investigation."xsd:string |
| http://purl.uniprot.org/citations/24365237 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.peptides.2013.11.021"xsd:string |
| http://purl.uniprot.org/citations/24365237 | http://purl.uniprot.org/core/author | "Robinson M.K."xsd:string |
| http://purl.uniprot.org/citations/24365237 | http://purl.uniprot.org/core/author | "Ashley S.W."xsd:string |
| http://purl.uniprot.org/citations/24365237 | http://purl.uniprot.org/core/author | "Waseem T."xsd:string |
| http://purl.uniprot.org/citations/24365237 | http://purl.uniprot.org/core/author | "Duxbury M."xsd:string |
| http://purl.uniprot.org/citations/24365237 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24365237 | http://purl.uniprot.org/core/name | "Peptides"xsd:string |
| http://purl.uniprot.org/citations/24365237 | http://purl.uniprot.org/core/pages | "113-121"xsd:string |
| http://purl.uniprot.org/citations/24365237 | http://purl.uniprot.org/core/title | "Ghrelin promotes intestinal epithelial cell proliferation through PI3K/Akt pathway and EGFR trans-activation both converging to ERK 1/2 phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/24365237 | http://purl.uniprot.org/core/volume | "52"xsd:string |
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