| http://purl.uniprot.org/citations/24366874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24366874 | http://www.w3.org/2000/01/rdf-schema#comment | "Under conditions of DNA damage, the mammalian target of rapamycin complex 1 (mTORC1) is inhibited, preventing cell cycle progression and conserving cellular energy by suppressing translation. We show that suppression of mTORC1 signaling to 4E-BP1 requires the coordinated activity of two tumor suppressors, p53 and p63. In contrast, suppression of S6K1 and ribosomal protein S6 phosphorylation by DNA damage is Akt-dependent. We find that loss of either p53, required for the induction of Sestrin 1/2, or p63, required for the induction of REDD1 and activation of the tuberous sclerosis complex, prevents the DNA damage-induced suppression of mTORC1 signaling. These data indicate that the negative regulation of cap-dependent translation by mTORC1 inhibition subsequent to DNA damage is abrogated in most human cancers."xsd:string |
| http://purl.uniprot.org/citations/24366874 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m113.530303"xsd:string |
| http://purl.uniprot.org/citations/24366874 | http://purl.uniprot.org/core/author | "Xiao L."xsd:string |
| http://purl.uniprot.org/citations/24366874 | http://purl.uniprot.org/core/author | "Zambetti G.P."xsd:string |
| http://purl.uniprot.org/citations/24366874 | http://purl.uniprot.org/core/author | "Cam H."xsd:string |
| http://purl.uniprot.org/citations/24366874 | http://purl.uniprot.org/core/author | "Cam M."xsd:string |
| http://purl.uniprot.org/citations/24366874 | http://purl.uniprot.org/core/author | "Houghton P.J."xsd:string |
| http://purl.uniprot.org/citations/24366874 | http://purl.uniprot.org/core/author | "Bid H.K."xsd:string |
| http://purl.uniprot.org/citations/24366874 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24366874 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/24366874 | http://purl.uniprot.org/core/pages | "4083-4094"xsd:string |
| http://purl.uniprot.org/citations/24366874 | http://purl.uniprot.org/core/title | "p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage."xsd:string |
| http://purl.uniprot.org/citations/24366874 | http://purl.uniprot.org/core/volume | "289"xsd:string |
| http://purl.uniprot.org/citations/24366874 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24366874 |
| http://purl.uniprot.org/citations/24366874 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24366874 |
| http://purl.uniprot.org/uniprot/#_A0A141PNN3-mappedCitation-24366874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24366874 |
| http://purl.uniprot.org/uniprot/#_A0A141PNN4-mappedCitation-24366874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24366874 |
| http://purl.uniprot.org/uniprot/#_A0A0M4B4Y9-mappedCitation-24366874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24366874 |
| http://purl.uniprot.org/uniprot/#_A0A087WXZ1-mappedCitation-24366874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24366874 |
| http://purl.uniprot.org/uniprot/#_A0A0C4KX50-mappedCitation-24366874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24366874 |
| http://purl.uniprot.org/uniprot/#_A0A0C4L134-mappedCitation-24366874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24366874 |
| http://purl.uniprot.org/uniprot/#_A0A087X1Q1-mappedCitation-24366874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24366874 |
| http://purl.uniprot.org/uniprot/#_A0A218MJE5-mappedCitation-24366874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24366874 |
| http://purl.uniprot.org/uniprot/#_A0A087WT22-mappedCitation-24366874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24366874 |