| http://purl.uniprot.org/citations/24367002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24367002 | http://www.w3.org/2000/01/rdf-schema#comment | "Signal transducer and activator of transcription 5 (Stat5) is essential for cytokine-regulated processes such as proliferation, differentiation, and survival in hematopoietic cells. To investigate the role of Stat5 in osteoclasts, we generated mice with an osteoclast-specific conditional deletion of Stat5 (Stat5 conditional knockout [cKO] mice) and analyzed their bone phenotype. Stat5 cKO mice exhibited osteoporosis caused by an increased bone-resorbing activity of osteoclasts. The activity of mitogen-activated protein kinases (MAPKs), in particular extracellular signal-related kinase, was increased in Stat5 cKO osteoclasts, whereas the expression of the MAPK phosphatases dual specificity phosphatase 1 (Dusp1) and Dusp2 was significantly decreased. Interleukin-3 (IL-3) stimulated the phosphorylation and nuclear translocation of Stat5 in osteoclasts, and Stat5 expression was up-regulated in response to receptor activator of nuclear factor κB ligand (RANKL). The results suggest that Stat5 negatively regulates the bone-resorbing function of osteoclasts by promoting Dusp1 and Dusp2 expression, and IL-3 promotes Stat5 activation in osteoclasts."xsd:string |
| http://purl.uniprot.org/citations/24367002 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20130538"xsd:string |
| http://purl.uniprot.org/citations/24367002 | http://purl.uniprot.org/core/author | "Matsumoto T."xsd:string |
| http://purl.uniprot.org/citations/24367002 | http://purl.uniprot.org/core/author | "Tanaka S."xsd:string |
| http://purl.uniprot.org/citations/24367002 | http://purl.uniprot.org/core/author | "Masuda H."xsd:string |
| http://purl.uniprot.org/citations/24367002 | http://purl.uniprot.org/core/author | "Yasui T."xsd:string |
| http://purl.uniprot.org/citations/24367002 | http://purl.uniprot.org/core/author | "Hirose J."xsd:string |
| http://purl.uniprot.org/citations/24367002 | http://purl.uniprot.org/core/author | "Kadono Y."xsd:string |
| http://purl.uniprot.org/citations/24367002 | http://purl.uniprot.org/core/author | "Omata Y."xsd:string |
| http://purl.uniprot.org/citations/24367002 | http://purl.uniprot.org/core/author | "Hennighausen L."xsd:string |
| http://purl.uniprot.org/citations/24367002 | http://purl.uniprot.org/core/author | "Tokuyama N."xsd:string |
| http://purl.uniprot.org/citations/24367002 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24367002 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/24367002 | http://purl.uniprot.org/core/pages | "153-163"xsd:string |
| http://purl.uniprot.org/citations/24367002 | http://purl.uniprot.org/core/title | "Bone resorption is regulated by cell-autonomous negative feedback loop of Stat5-Dusp axis in the osteoclast."xsd:string |
| http://purl.uniprot.org/citations/24367002 | http://purl.uniprot.org/core/volume | "211"xsd:string |
| http://purl.uniprot.org/citations/24367002 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24367002 |
| http://purl.uniprot.org/citations/24367002 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24367002 |
| http://purl.uniprot.org/uniprot/#_Q0PMN2-mappedCitation-24367002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24367002 |
| http://purl.uniprot.org/uniprot/#_A2A5D3-mappedCitation-24367002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24367002 |
| http://purl.uniprot.org/uniprot/#_A2A5D4-mappedCitation-24367002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24367002 |
| http://purl.uniprot.org/uniprot/#_B2C3G8-mappedCitation-24367002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24367002 |
| http://purl.uniprot.org/uniprot/#_Q71UV3-mappedCitation-24367002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24367002 |
| http://purl.uniprot.org/uniprot/#_Q3UZ79-mappedCitation-24367002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24367002 |