| http://purl.uniprot.org/citations/24371268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24371268 | http://www.w3.org/2000/01/rdf-schema#comment | "MUS81 plays important cellular roles in the restart of stalled replication forks, the resolution of recombination intermediates and in telomere length maintenance. Although the actions of MUS81-EME1 have been extensively investigated, MUS81 is the catalytic subunit of two human structure-selective endonucleases, MUS81-EME1 and MUS81-EME2. Little is presently known about the activities of MUS81-EME2. Here, we have purified MUS81-EME2 and compared its activities with MUS81-EME1. We find that MUS81-EME2 is a more active endonuclease than MUS81-EME1 and exhibits broader substrate specificity. Like MUS81-EME1, MUS81-EME2 cleaves 3'-flaps, replication forks and nicked Holliday junctions, and exhibits limited endonuclease activity with intact Holliday junctions. In contrast to MUS81-EME1, however, MUS81-EME2 cuts D-loop recombination intermediates and in so doing disengages the D-loop structure by cleaving the 3'-invading strand. Additionally, MUS81-EME2 acts on 5'-flap structures to cleave off a duplex arm, in reactions that cannot be promoted by MUS81-EME1. These studies suggest that MUS81-EME1 and MUS81-EME2 exhibit similar and yet distinct DNA structure selectivity, indicating that the two MUS81 complexes may promote different nucleolytic cleavage reactions in vivo."xsd:string |
| http://purl.uniprot.org/citations/24371268 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkt1333"xsd:string |
| http://purl.uniprot.org/citations/24371268 | http://purl.uniprot.org/core/author | "West S.C."xsd:string |
| http://purl.uniprot.org/citations/24371268 | http://purl.uniprot.org/core/author | "Pepe A."xsd:string |
| http://purl.uniprot.org/citations/24371268 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24371268 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/24371268 | http://purl.uniprot.org/core/pages | "3833-3845"xsd:string |
| http://purl.uniprot.org/citations/24371268 | http://purl.uniprot.org/core/title | "Substrate specificity of the MUS81-EME2 structure selective endonuclease."xsd:string |
| http://purl.uniprot.org/citations/24371268 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/24371268 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24371268 |
| http://purl.uniprot.org/citations/24371268 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24371268 |
| http://purl.uniprot.org/uniprot/#_P54132-mappedCitation-24371268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24371268 |
| http://purl.uniprot.org/uniprot/#_Q14191-mappedCitation-24371268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24371268 |
| http://purl.uniprot.org/uniprot/#_A4GXA9-mappedCitation-24371268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24371268 |
| http://purl.uniprot.org/uniprot/#_O15315-mappedCitation-24371268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24371268 |
| http://purl.uniprot.org/uniprot/#_P49959-mappedCitation-24371268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24371268 |
| http://purl.uniprot.org/uniprot/#_Q13472-mappedCitation-24371268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24371268 |
| http://purl.uniprot.org/uniprot/#_P38398-mappedCitation-24371268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24371268 |
| http://purl.uniprot.org/uniprot/#_Q06609-mappedCitation-24371268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24371268 |
| http://purl.uniprot.org/uniprot/#_O75771-mappedCitation-24371268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24371268 |
| http://purl.uniprot.org/uniprot/#_Q86YC2-mappedCitation-24371268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24371268 |
| http://purl.uniprot.org/uniprot/#_O43502-mappedCitation-24371268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24371268 |
| http://purl.uniprot.org/uniprot/#_O60934-mappedCitation-24371268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24371268 |
| http://purl.uniprot.org/uniprot/#_O43542-mappedCitation-24371268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24371268 |