| http://purl.uniprot.org/citations/24374234 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24374234 | http://www.w3.org/2000/01/rdf-schema#comment | "Insulin stimulated glucose uptake requires the colocalization of myosin IIA (MyoIIA) and the insulin-responsive glucose transporter 4 (GLUT4) at the plasma membrane for proper GLUT4 fusion. MyoIIA facilitates filamentous actin (F-actin) reorganization in various cell types. In adipocytes F-actin reorganization is required for insulin-stimulated glucose uptake. What is not known is whether MyoIIA interacts with F-actin to regulate insulin-induced GLUT4 fusion at the plasma membrane. To elucidate the relationship between MyoIIA and F-actin, we examined the colocalization of MyoIIA and F-actin at the plasma membrane upon insulin stimulation as well as the regulation of this interaction. Our findings demonstrated that MyoIIA and F-actin colocalized at the site of GLUT4 fusion with the plasma membrane upon insulin stimulation. Furthermore, inhibition of MyoII with blebbistatin impaired F-actin localization at the plasma membrane. Next we examined the regulatory role of calcium in MyoIIA-F-actin colocalization. Reduced calcium or calmodulin levels decreased colocalization of MyoIIA and F-actin at the plasma membrane. While calcium alone can translocate MyoIIA it did not stimulate F-actin accumulation at the plasma membrane. Taken together, we established that while MyoIIA activity is required for F-actin localization at the plasma membrane, it alone is insufficient to localize F-actin to the plasma membrane."xsd:string |
| http://purl.uniprot.org/citations/24374234 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2013.12.011"xsd:string |
| http://purl.uniprot.org/citations/24374234 | http://purl.uniprot.org/core/author | "Ramos J."xsd:string |
| http://purl.uniprot.org/citations/24374234 | http://purl.uniprot.org/core/author | "Patel Y.M."xsd:string |
| http://purl.uniprot.org/citations/24374234 | http://purl.uniprot.org/core/author | "Stall R."xsd:string |
| http://purl.uniprot.org/citations/24374234 | http://purl.uniprot.org/core/author | "Kent Fulcher F."xsd:string |
| http://purl.uniprot.org/citations/24374234 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24374234 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/24374234 | http://purl.uniprot.org/core/pages | "81-88"xsd:string |
| http://purl.uniprot.org/citations/24374234 | http://purl.uniprot.org/core/title | "Regulation of myosin IIA and filamentous actin during insulin-stimulated glucose uptake in 3T3-L1 adipocytes."xsd:string |
| http://purl.uniprot.org/citations/24374234 | http://purl.uniprot.org/core/volume | "322"xsd:string |
| http://purl.uniprot.org/citations/24374234 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24374234 |
| http://purl.uniprot.org/citations/24374234 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24374234 |
| http://purl.uniprot.org/uniprot/#_P11233-mappedCitation-24374234 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24374234 |
| http://purl.uniprot.org/uniprot/#_A2VCK0-mappedCitation-24374234 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24374234 |
| http://purl.uniprot.org/uniprot/#_P35579-mappedCitation-24374234 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24374234 |
| http://purl.uniprot.org/uniprot/#_Q14B05-mappedCitation-24374234 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24374234 |
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| http://purl.uniprot.org/uniprot/#_Q99JJ3-mappedCitation-24374234 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24374234 |
| http://purl.uniprot.org/uniprot/#_Q3UFT0-mappedCitation-24374234 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24374234 |
| http://purl.uniprot.org/uniprot/#_O00471-mappedCitation-24374234 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24374234 |
| http://purl.uniprot.org/uniprot/#_O60645-mappedCitation-24374234 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24374234 |
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| http://purl.uniprot.org/uniprot/#_P51153-mappedCitation-24374234 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24374234 |