| http://purl.uniprot.org/citations/24375836 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24375836 | http://www.w3.org/2000/01/rdf-schema#comment | "AZD6244, an ATP-uncompetitive inhibitor of mitogen-activated protein kinase 1/2 (MEK1/2), has shown activity in several malignant tumours. However, whether AZD6244 has a function in lymphoma cells is not known. We report that AZD6244 treatment represses the growth of Raji and MOLT4 cells by inducing apoptosis and G1-phase arrest. Using miRNAs array and quantitative RT-PCR, miR-92a was downregulated byAZD6244 treatment through the ERK1/2-AP1 signalling pathway. Overexpression of miR-92a abrogated AZD6244-induced apoptosis and G1-phase arrest, indicating that it is involved in the cytotoxicity of AZD6244 in lymphoma cells. A luciferase reporter assay showed that miR-92a directly targetsthe 3'-UTRs of Bim. Overexpression of miR-92a mimics downregulated Bim mRNA and protein expression level, indicating that miR-92a negatively regulates its expression at both levels. Silencing Bim decreases AZD6244-induced apoptosis and G1-phase arrest, suggesting that Bim contributes to the growth arrest. Thus, miR-92a mediates AZD6244-induced cytotoxicity of lymphoma cells by targeting Bim. Downregulation of miR-92a by AZD6244 is mediated by the ERK1/2-AP1 signalling pathway."xsd:string |
| http://purl.uniprot.org/citations/24375836 | http://purl.org/dc/terms/identifier | "doi:10.1002/cbin.10225"xsd:string |
| http://purl.uniprot.org/citations/24375836 | http://purl.uniprot.org/core/author | "Jiang L."xsd:string |
| http://purl.uniprot.org/citations/24375836 | http://purl.uniprot.org/core/author | "Lu Z."xsd:string |
| http://purl.uniprot.org/citations/24375836 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/24375836 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/24375836 | http://purl.uniprot.org/core/author | "Meng W."xsd:string |
| http://purl.uniprot.org/citations/24375836 | http://purl.uniprot.org/core/author | "Deng L."xsd:string |
| http://purl.uniprot.org/citations/24375836 | http://purl.uniprot.org/core/author | "Lv X.B."xsd:string |
| http://purl.uniprot.org/citations/24375836 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24375836 | http://purl.uniprot.org/core/name | "Cell Biol Int"xsd:string |
| http://purl.uniprot.org/citations/24375836 | http://purl.uniprot.org/core/pages | "435-443"xsd:string |
| http://purl.uniprot.org/citations/24375836 | http://purl.uniprot.org/core/title | "MiR-92a mediates AZD6244 induced apoptosis and G1-phase arrest of lymphoma cells by targeting Bim."xsd:string |
| http://purl.uniprot.org/citations/24375836 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/24375836 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24375836 |
| http://purl.uniprot.org/citations/24375836 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24375836 |
| http://purl.uniprot.org/uniprot/P05412#attribution-0A6F7B216ED5BA84E8714DDE3417820D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24375836 |
| http://purl.uniprot.org/uniprot/Q02750#attribution-0A6F7B216ED5BA84E8714DDE3417820D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24375836 |
| http://purl.uniprot.org/uniprot/P36507#attribution-0A6F7B216ED5BA84E8714DDE3417820D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24375836 |