| http://purl.uniprot.org/citations/24378362 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24378362 | http://www.w3.org/2000/01/rdf-schema#comment | "Cell-cell adhesions induce various intracellular signals through hierarchical and synergistic molecular interactions. Recently, we demonstrated that a high cell density induces the expression of vascular cell adhesion molecule-1 (VCAM-1) through the nuclear factor-κB (NF-κB) pathway in human bone marrow-derived mesenchymal stem cells (MSCs). However, the specific molecules that activated the NF-κB pathway were not determined. In the present study, in experiments with receptor tyrosine kinase inhibitors, VCAM-1 expression was completely suppressed by platelet-derived growth factor (PDGF) receptor (PDGFR) inhibitors. In addition, VCAM-1 expression was significantly suppressed by knockdown with PDGFRβ siRNA, but not with PDGFRα siRNA. However, VCAM-1 expression did not increase following treatment with PDGF. The overexpression of N-cadherin, a structural molecule in adherence junctions in MSCs, promoted VCAM-1 expression and induced the marked phosphorylation of the intracellular signaling factor, Src. In addition, VCAM-1 expression and Src phosphorylation were reduced by the overexpression of a dominant negative mutant of N-cadherin. These results suggest that cell-cell adhesion, through N-cadherin, enhances the expression of VCAM-1 via PDGFRβ and the activation of Src in a ligand-independent manner in MSCs."xsd:string |
| http://purl.uniprot.org/citations/24378362 | http://purl.org/dc/terms/identifier | "doi:10.3892/ijmm.2013.1607"xsd:string |
| http://purl.uniprot.org/citations/24378362 | http://purl.uniprot.org/core/author | "Miura H."xsd:string |
| http://purl.uniprot.org/citations/24378362 | http://purl.uniprot.org/core/author | "Sugiyama Y."xsd:string |
| http://purl.uniprot.org/citations/24378362 | http://purl.uniprot.org/core/author | "Chosa N."xsd:string |
| http://purl.uniprot.org/citations/24378362 | http://purl.uniprot.org/core/author | "Ishisaki A."xsd:string |
| http://purl.uniprot.org/citations/24378362 | http://purl.uniprot.org/core/author | "Aomatsu E."xsd:string |
| http://purl.uniprot.org/citations/24378362 | http://purl.uniprot.org/core/author | "Nishihira S."xsd:string |
| http://purl.uniprot.org/citations/24378362 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24378362 | http://purl.uniprot.org/core/name | "Int J Mol Med"xsd:string |
| http://purl.uniprot.org/citations/24378362 | http://purl.uniprot.org/core/pages | "565-572"xsd:string |
| http://purl.uniprot.org/citations/24378362 | http://purl.uniprot.org/core/title | "Cell-cell adhesion through N-cadherin enhances VCAM-1 expression via PDGFRbeta in a ligand-independent manner in mesenchymal stem cells."xsd:string |
| http://purl.uniprot.org/citations/24378362 | http://purl.uniprot.org/core/volume | "33"xsd:string |
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