| http://purl.uniprot.org/citations/24378640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24378640 | http://www.w3.org/2000/01/rdf-schema#comment | "Loss of primary cilia is a key feature of von Hippel-Lindau tumor suppressor (VHL)-associated pathology. Although VHL-deficiency predisposes cells to precipitous cilia disassembly in response to growth factor cues, it does not affect ciliogenesis. Here, using a siRNA-based screen to find genes that are essential for ciliogenesis only in the presence of the VHL tumor suppressor gene product pVHL, we identify ubiquitin-specific protease (USP)8. The pVHL-dependency of USP8 for ciliogenesis is directly linked to its function as a HIF1α deubiquitinating enzyme. By counteracting pVHL-mediated ubiquitination of HIF1α, USP8 maintains a basal expression of HIF1α and HIF transcriptional output in normoxia, including the repression of Rabaptin5, which is essential for endosome trafficking-mediated ciliogenesis."xsd:string |
| http://purl.uniprot.org/citations/24378640 | http://purl.org/dc/terms/identifier | "doi:10.1002/embr.201337688"xsd:string |
| http://purl.uniprot.org/citations/24378640 | http://purl.uniprot.org/core/author | "Muehl S."xsd:string |
| http://purl.uniprot.org/citations/24378640 | http://purl.uniprot.org/core/author | "Krek W."xsd:string |
| http://purl.uniprot.org/citations/24378640 | http://purl.uniprot.org/core/author | "Knobeloch K.P."xsd:string |
| http://purl.uniprot.org/citations/24378640 | http://purl.uniprot.org/core/author | "Troilo A."xsd:string |
| http://purl.uniprot.org/citations/24378640 | http://purl.uniprot.org/core/author | "Jaramillo D."xsd:string |
| http://purl.uniprot.org/citations/24378640 | http://purl.uniprot.org/core/author | "Alexander I."xsd:string |
| http://purl.uniprot.org/citations/24378640 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24378640 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/24378640 | http://purl.uniprot.org/core/pages | "77-85"xsd:string |
| http://purl.uniprot.org/citations/24378640 | http://purl.uniprot.org/core/title | "HIF1alpha deubiquitination by USP8 is essential for ciliogenesis in normoxia."xsd:string |
| http://purl.uniprot.org/citations/24378640 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/24378640 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24378640 |
| http://purl.uniprot.org/citations/24378640 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24378640 |
| http://purl.uniprot.org/uniprot/#_P40818-mappedCitation-24378640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24378640 |
| http://purl.uniprot.org/uniprot/#_Q16665-mappedCitation-24378640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24378640 |
| http://purl.uniprot.org/uniprot/#_Q99814-mappedCitation-24378640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24378640 |
| http://purl.uniprot.org/uniprot/P40818 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24378640 |
| http://purl.uniprot.org/uniprot/Q99814 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24378640 |
| http://purl.uniprot.org/uniprot/Q16665 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24378640 |