| http://purl.uniprot.org/citations/24379125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24379125 | http://www.w3.org/2000/01/rdf-schema#comment | "The innate-like T cells expressing Vγ1.1 and Vδ6.3 represent a unique T cell lineage sharing features with both the γδ T and the invariant NKT cells. The population size of Vγ1.1(+)Vδ6.3(+) T cells is tightly controlled and usually contributes to a very small proportion of thymic output, but the underlying mechanism remains enigmatic. Deletion of Id3, an inhibitor of E protein transcription factors, can induce an expansion of the Vγ1.1(+)Vδ6.3(+) T cell population. This phenotype is much stronger on the C57BL/6 background than on the 129/sv background. Using quantitative trait linkage analysis, we identified Id2, a homolog of Id3, to be the major modifier of Id3 in limiting Vγ1.1(+)Vδ6.3(+) T cell expansion. The Vγ1.1(+)Vδ6.3(+) phenotype is attributed to an intrinsic weakness of Id2 transcription from Id2 C57BL/6 allele, leading to an overall reduced dosage of Id proteins. However, complete removal of both Id2 and Id3 genes in developing T cells suppressed the expansion of Vγ1.1(+)Vδ6.3(+) T cells because of decreased proliferation and increased cell death. We showed that conditional knockout of Id2 alone is sufficient to promote a moderate expansion of γδ T cells. These regulatory effects of Id2 and Id3 on Vγ1.1(+)Vδ6.3(+) T cells are mediated by titration of E protein activity, because removing one or more copies of E protein genes can restore Vγ1.1(+)Vδ6.3(+) T cell expansion in Id2 and Id3 double conditional knockout mice. Our data indicated that Id2 and Id3 collaboratively control survival and expansion of the γδ lineage through modulating a proper threshold of E proteins."xsd:string |
| http://purl.uniprot.org/citations/24379125 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1302694"xsd:string |
| http://purl.uniprot.org/citations/24379125 | http://purl.uniprot.org/core/author | "Zhang B."xsd:string |
| http://purl.uniprot.org/citations/24379125 | http://purl.uniprot.org/core/author | "Dai M."xsd:string |
| http://purl.uniprot.org/citations/24379125 | http://purl.uniprot.org/core/author | "Lin Y.Y."xsd:string |
| http://purl.uniprot.org/citations/24379125 | http://purl.uniprot.org/core/author | "Zhuang Y."xsd:string |
| http://purl.uniprot.org/citations/24379125 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24379125 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/24379125 | http://purl.uniprot.org/core/pages | "1055-1063"xsd:string |
| http://purl.uniprot.org/citations/24379125 | http://purl.uniprot.org/core/title | "Id3 and Id2 act as a dual safety mechanism in regulating the development and population size of innate-like gammadelta T cells."xsd:string |
| http://purl.uniprot.org/citations/24379125 | http://purl.uniprot.org/core/volume | "192"xsd:string |
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