| http://purl.uniprot.org/citations/24379354 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24379354 | http://www.w3.org/2000/01/rdf-schema#comment | "Pancreatic β-cell dysfunction is a common feature of type 2 diabetes. Earlier, we had cloned IG20 cDNA from a human insulinoma and had shown that IG20/MADD can encode six different splice isoforms that are differentially expressed and have unique functions, but its role in β-cell function was unexplored. To investigate the role of IG20/MADD in β-cell function, we generated conditional knockout (KMA1ko) mice. Deletion of IG20/MADD in β-cells resulted in hyperglycemia and glucose intolerance associated with reduced and delayed glucose-induced insulin production. KMA1ko β-cells were able to process insulin normally but had increased insulin accumulation and showed a severe defect in glucose-induced insulin release. These findings indicated that IG20/MADD plays a critical role in glucose-induced insulin release from β-cells and that its functional disruption can cause type 2 diabetes. The clinical relevance of these findings is highlighted by recent reports of very strong association of the rs7944584 single nucleotide polymorphism (SNP) of IG20/MADD with fasting hyperglycemia/diabetes. Thus, IG20/MADD could be a therapeutic target for type 2 diabetes, particularly in those with the rs7944584 SNP."xsd:string |
| http://purl.uniprot.org/citations/24379354 | http://purl.org/dc/terms/identifier | "doi:10.2337/db13-0707"xsd:string |
| http://purl.uniprot.org/citations/24379354 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/24379354 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/24379354 | http://purl.uniprot.org/core/author | "Wang Q."xsd:string |
| http://purl.uniprot.org/citations/24379354 | http://purl.uniprot.org/core/author | "Qian L."xsd:string |
| http://purl.uniprot.org/citations/24379354 | http://purl.uniprot.org/core/author | "Li L.C."xsd:string |
| http://purl.uniprot.org/citations/24379354 | http://purl.uniprot.org/core/author | "Prabhakar B.S."xsd:string |
| http://purl.uniprot.org/citations/24379354 | http://purl.uniprot.org/core/author | "Carr R."xsd:string |
| http://purl.uniprot.org/citations/24379354 | http://purl.uniprot.org/core/author | "Oberholzer J."xsd:string |
| http://purl.uniprot.org/citations/24379354 | http://purl.uniprot.org/core/author | "Maker A.V."xsd:string |
| http://purl.uniprot.org/citations/24379354 | http://purl.uniprot.org/core/author | "Haddad C.S."xsd:string |
| http://purl.uniprot.org/citations/24379354 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24379354 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
| http://purl.uniprot.org/citations/24379354 | http://purl.uniprot.org/core/pages | "1612-1623"xsd:string |
| http://purl.uniprot.org/citations/24379354 | http://purl.uniprot.org/core/title | "IG20/MADD plays a critical role in glucose-induced insulin secretion."xsd:string |
| http://purl.uniprot.org/citations/24379354 | http://purl.uniprot.org/core/volume | "63"xsd:string |
| http://purl.uniprot.org/citations/24379354 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24379354 |
| http://purl.uniprot.org/citations/24379354 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24379354 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1F4-mappedCitation-24379354 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24379354 |
| http://purl.uniprot.org/uniprot/#_A2AGQ2-mappedCitation-24379354 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24379354 |
| http://purl.uniprot.org/uniprot/#_A2AGQ3-mappedCitation-24379354 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24379354 |
| http://purl.uniprot.org/uniprot/#_A2AGQ4-mappedCitation-24379354 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24379354 |
| http://purl.uniprot.org/uniprot/#_A2AGQ5-mappedCitation-24379354 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24379354 |