| http://purl.uniprot.org/citations/24385540 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24385540 | http://www.w3.org/2000/01/rdf-schema#comment | "In this study, we show that microRNA-150 (miR-150) is significantly downregulated in advanced cutaneous T-cell lymphoma (CTCL), and that this downregulation is strongly associated with tumor invasion/metastasis. Inoculation of CTCL cell lines into nonobese diabetic/Shi-scid interleukin 2γ (IL-2γ) null mice led to CTCL cell migration to multiple organs; however, prior transfection of the cells with miR-150 substantially reduced the invasion/metastasis by directly downregulating CCR6, a specific receptor for the chemokine CCL20. We also found that IL-22 and its specific receptor subunit, IL22RA1, were aberrantly overexpressed in advanced CTCL, and that production of IL-22 and CCL20 was increased in cultured CTCL cells. IL22RA1 knockdown specifically reduced CCL20 production in CTCL cells, suggesting that IL-22 upregulation may activate the production of CCL20 and its binding to CCR6, thereby enhancing the multidirectional migration potential of CTCL cells. CTCL cells also exhibited nutrition- and CCL20-dependent chemotaxis, which were inhibited by miR-150 transfection or CCR6 knockdown. From these findings, we conclude that, in the presence of continuous CCR6 upregulation accompanied by miR-150 downregulation, IL-22 activation leads to continuous CCL20-CCR6 interaction in CTCL cells and, in turn, autocrine metastasis to distal organs. This suggests miR-150, CCL20, and CCR6 could be key targets for the treatment of advanced CTCL."xsd:string |
| http://purl.uniprot.org/citations/24385540 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2013-09-527739"xsd:string |
| http://purl.uniprot.org/citations/24385540 | http://purl.uniprot.org/core/author | "Ito M."xsd:string |
| http://purl.uniprot.org/citations/24385540 | http://purl.uniprot.org/core/author | "Ohshima K."xsd:string |
| http://purl.uniprot.org/citations/24385540 | http://purl.uniprot.org/core/author | "Watanabe A."xsd:string |
| http://purl.uniprot.org/citations/24385540 | http://purl.uniprot.org/core/author | "Yamashita J."xsd:string |
| http://purl.uniprot.org/citations/24385540 | http://purl.uniprot.org/core/author | "Sawada K."xsd:string |
| http://purl.uniprot.org/citations/24385540 | http://purl.uniprot.org/core/author | "Ikeda S."xsd:string |
| http://purl.uniprot.org/citations/24385540 | http://purl.uniprot.org/core/author | "Teshima K."xsd:string |
| http://purl.uniprot.org/citations/24385540 | http://purl.uniprot.org/core/author | "Tagawa H."xsd:string |
| http://purl.uniprot.org/citations/24385540 | http://purl.uniprot.org/core/author | "Nara M."xsd:string |
| http://purl.uniprot.org/citations/24385540 | http://purl.uniprot.org/core/author | "Kitadate A."xsd:string |
| http://purl.uniprot.org/citations/24385540 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24385540 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/24385540 | http://purl.uniprot.org/core/pages | "1499-1511"xsd:string |
| http://purl.uniprot.org/citations/24385540 | http://purl.uniprot.org/core/title | "MicroRNA-150 inhibits tumor invasion and metastasis by targeting the chemokine receptor CCR6, in advanced cutaneous T-cell lymphoma."xsd:string |
| http://purl.uniprot.org/citations/24385540 | http://purl.uniprot.org/core/volume | "123"xsd:string |
| http://purl.uniprot.org/citations/24385540 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24385540 |
| http://purl.uniprot.org/citations/24385540 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24385540 |
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| http://purl.uniprot.org/uniprot/#_Q53EZ5-mappedCitation-24385540 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24385540 |
| http://purl.uniprot.org/uniprot/#_P51684-mappedCitation-24385540 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24385540 |
| http://purl.uniprot.org/uniprot/P51684 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24385540 |
| http://purl.uniprot.org/uniprot/A8KAF0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24385540 |