| http://purl.uniprot.org/citations/24389026 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24389026 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24389026 | http://www.w3.org/2000/01/rdf-schema#comment | "The combination of an E2 ubiquitin-conjugating enzyme with an E3 ubiquitin-ligase is essential for ubiquitin modification of a substrate. Moreover, the pairing dictates both the substrate choice and the modification type. The molecular details of generic E3-E2 interactions are well established. Nevertheless, the determinants of selective, specific E3-E2 recognition are not understood. There are ∼40 E2s and ∼600 E3s giving rise to a possible ∼24,000 E3-E2 pairs. Using the Fanconi Anemia pathway exclusive E3-E2 pair, FANCL-Ube2T, we report the atomic structure of the FANCL RING-Ube2T complex, revealing a specific and extensive network of additional electrostatic and hydrophobic interactions. Furthermore, we show that these specific interactions are required for selection of Ube2T over other E2s by FANCL."xsd:string |
| http://purl.uniprot.org/citations/24389026 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2013.12.004"xsd:string |
| http://purl.uniprot.org/citations/24389026 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2013.12.004"xsd:string |
| http://purl.uniprot.org/citations/24389026 | http://purl.uniprot.org/core/author | "Walden H."xsd:string |
| http://purl.uniprot.org/citations/24389026 | http://purl.uniprot.org/core/author | "Walden H."xsd:string |
| http://purl.uniprot.org/citations/24389026 | http://purl.uniprot.org/core/author | "Hodson C."xsd:string |
| http://purl.uniprot.org/citations/24389026 | http://purl.uniprot.org/core/author | "Hodson C."xsd:string |
| http://purl.uniprot.org/citations/24389026 | http://purl.uniprot.org/core/author | "Miles J.A."xsd:string |
| http://purl.uniprot.org/citations/24389026 | http://purl.uniprot.org/core/author | "Miles J.A."xsd:string |
| http://purl.uniprot.org/citations/24389026 | http://purl.uniprot.org/core/author | "Purkiss A."xsd:string |
| http://purl.uniprot.org/citations/24389026 | http://purl.uniprot.org/core/author | "Purkiss A."xsd:string |
| http://purl.uniprot.org/citations/24389026 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24389026 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24389026 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/24389026 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/24389026 | http://purl.uniprot.org/core/pages | "337-344"xsd:string |
| http://purl.uniprot.org/citations/24389026 | http://purl.uniprot.org/core/pages | "337-344"xsd:string |
| http://purl.uniprot.org/citations/24389026 | http://purl.uniprot.org/core/title | "Structure of the human FANCL RING-Ube2T complex reveals determinants of cognate E3-E2 selection."xsd:string |
| http://purl.uniprot.org/citations/24389026 | http://purl.uniprot.org/core/title | "Structure of the human FANCL RING-Ube2T complex reveals determinants of cognate E3-E2 selection."xsd:string |
| http://purl.uniprot.org/citations/24389026 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/24389026 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/24389026 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24389026 |
| http://purl.uniprot.org/citations/24389026 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24389026 |