| http://purl.uniprot.org/citations/24390364 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24390364 | http://www.w3.org/2000/01/rdf-schema#comment | "Signal peptide-CUB-EGF-like domain-containing protein 3 (SCUBE3) is highly expressed in invasive lung cancers. In vitro investigation indicated that SCUBE3 may play a critical role in lung cancer invasion and metastasis. The current study immunohistochemically investigated the expression of SCUBE3 in 119 cases of non-small cell lung cancer (NSCLC) tumors and this study evaluated its clinical-pathological and prognostic significance. SCUBE3 was found to be up-regulated in NSCLC tissue samples compared to adjacent normal tissue. High SCUBE3 expression was noted in 84/119 (70.6%) of NSCLC tissue samples and was positively correlated with lymph node involvement (p = 0.001) and advanced stages of tumor/lymph node metastasis (TNM) (p = 0.014). Furthermore, high SCUBE3 expression was significantly associated with loss of the epithelial marker E-cadherin (p = 0.0015) and acquisition of expression of the mesenchymal marker vimentin (p = 0.005). Patients with high SCUBE3 expression had significantly a shorter survival time compared to patients with low SCUBE3 expression (p = 0.001), and SCUBE3 expression served as an independent prognostic factor for NSCLC patients. Results indicated that SCUBE3 might be involved in regulating the epithelial-mesenchymal transition (EMT) and malignant progression in NSCLC. Results also indicated that SCUBE3d may be a potential therapeutic target for lung cancers."xsd:string |
| http://purl.uniprot.org/citations/24390364 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/24390364 | http://purl.uniprot.org/core/author | "Gu M."xsd:string |
| http://purl.uniprot.org/citations/24390364 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/24390364 | http://purl.uniprot.org/core/author | "Wang Q."xsd:string |
| http://purl.uniprot.org/citations/24390364 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/24390364 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/24390364 | http://purl.uniprot.org/core/author | "Zhao C."xsd:string |
| http://purl.uniprot.org/citations/24390364 | http://purl.uniprot.org/core/author | "Deng A."xsd:string |
| http://purl.uniprot.org/citations/24390364 | http://purl.uniprot.org/core/author | "qin Q."xsd:string |
| http://purl.uniprot.org/citations/24390364 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24390364 | http://purl.uniprot.org/core/name | "Biosci Trends"xsd:string |
| http://purl.uniprot.org/citations/24390364 | http://purl.uniprot.org/core/pages | "264-269"xsd:string |
| http://purl.uniprot.org/citations/24390364 | http://purl.uniprot.org/core/title | "SCUBE3 overexpression predicts poor prognosis in non-small cell lung cancer."xsd:string |
| http://purl.uniprot.org/citations/24390364 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/24390364 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24390364 |
| http://purl.uniprot.org/citations/24390364 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24390364 |
| http://purl.uniprot.org/uniprot/#_Q5CZ68-mappedCitation-24390364 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24390364 |
| http://purl.uniprot.org/uniprot/#_Q7Z3I8-mappedCitation-24390364 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24390364 |
| http://purl.uniprot.org/uniprot/#_Q8IX30-mappedCitation-24390364 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24390364 |
| http://purl.uniprot.org/uniprot/#_Q8NAV8-mappedCitation-24390364 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24390364 |
| http://purl.uniprot.org/uniprot/Q8IX30 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24390364 |
| http://purl.uniprot.org/uniprot/Q8NAV8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24390364 |
| http://purl.uniprot.org/uniprot/Q5CZ68 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24390364 |