| http://purl.uniprot.org/citations/24391507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24391507 | http://www.w3.org/2000/01/rdf-schema#comment | "Infection with Listeria monocytogenes strains that enter the host cell cytosol leads to a robust cytotoxic T cell response resulting in long-lived cell-mediated immunity (CMI). Upon entry into the cytosol, L. monocytogenes secretes cyclic diadenosine monophosphate (c-di-AMP) which activates the innate immune sensor STING leading to the expression of IFN-β and co-regulated genes. In this study, we examined the role of STING in the development of protective CMI to L. monocytogenes. Mice deficient for STING or its downstream effector IRF3 restricted a secondary lethal challenge with L. monocytogenes and exhibited enhanced immunity that was MyD88-independent. Conversely, enhancing STING activation during immunization by co-administration of c-di-AMP or by infection with a L. monocytogenes mutant that secretes elevated levels of c-di-AMP resulted in decreased protective immunity that was largely dependent on the type I interferon receptor. These data suggest that L. monocytogenes activation of STING downregulates CMI by induction of type I interferon."xsd:string |
| http://purl.uniprot.org/citations/24391507 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.ppat.1003861"xsd:string |
| http://purl.uniprot.org/citations/24391507 | http://purl.uniprot.org/core/author | "Portnoy D.A."xsd:string |
| http://purl.uniprot.org/citations/24391507 | http://purl.uniprot.org/core/author | "Durack J."xsd:string |
| http://purl.uniprot.org/citations/24391507 | http://purl.uniprot.org/core/author | "Archer K.A."xsd:string |
| http://purl.uniprot.org/citations/24391507 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24391507 | http://purl.uniprot.org/core/name | "PLoS Pathog"xsd:string |
| http://purl.uniprot.org/citations/24391507 | http://purl.uniprot.org/core/pages | "e1003861"xsd:string |
| http://purl.uniprot.org/citations/24391507 | http://purl.uniprot.org/core/title | "STING-dependent type I IFN production inhibits cell-mediated immunity to Listeria monocytogenes."xsd:string |
| http://purl.uniprot.org/citations/24391507 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/24391507 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24391507 |
| http://purl.uniprot.org/citations/24391507 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24391507 |
| http://purl.uniprot.org/uniprot/#_A0A125R9I3-mappedCitation-24391507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24391507 |
| http://purl.uniprot.org/uniprot/#_P70671-mappedCitation-24391507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24391507 |
| http://purl.uniprot.org/uniprot/#_Q0PM15-mappedCitation-24391507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24391507 |
| http://purl.uniprot.org/uniprot/#_Q0PM16-mappedCitation-24391507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24391507 |
| http://purl.uniprot.org/uniprot/#_A0A140LHE6-mappedCitation-24391507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24391507 |
| http://purl.uniprot.org/uniprot/#_A0A140LI96-mappedCitation-24391507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24391507 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GRH7-mappedCitation-24391507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24391507 |
| http://purl.uniprot.org/uniprot/#_A0A2R3XZC4-mappedCitation-24391507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24391507 |
| http://purl.uniprot.org/uniprot/#_A0A140LJD9-mappedCitation-24391507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24391507 |
| http://purl.uniprot.org/uniprot/#_A0A140LJE8-mappedCitation-24391507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24391507 |
| http://purl.uniprot.org/uniprot/#_A0A1S5WLE4-mappedCitation-24391507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24391507 |
| http://purl.uniprot.org/uniprot/#_A0A494B980-mappedCitation-24391507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24391507 |