| http://purl.uniprot.org/citations/24394411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24394411 | http://www.w3.org/2000/01/rdf-schema#comment | "The ten-eleven translocation (TET) family of dioxygenases (TET1/2/3) converts 5-methylcytosine to 5-hydroxymethylcytosine and provides a vital mechanism for DNA demethylation. However, how TET proteins are regulated is largely unknown. Here we report that the O-linked β-GlcNAc (O-GlcNAc) transferase (OGT) is not only a major TET3-interacting protein but also regulates TET3 subcellular localization and enzymatic activity. OGT catalyzes the O-GlcNAcylation of TET3, promotes TET3 nuclear export, and, consequently, inhibits the formation of 5-hydroxymethylcytosine catalyzed by TET3. Although TET1 and TET2 also interact with and can be O-GlcNAcylated by OGT, neither their subcellular localization nor their enzymatic activity are affected by OGT. Furthermore, we show that the nuclear localization and O-GlcNAcylation of TET3 are regulated by glucose metabolism. Our study reveals the differential regulation of TET family proteins by OGT and a novel link between glucose metabolism and DNA epigenetic modification."xsd:string |
| http://purl.uniprot.org/citations/24394411 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m113.524140"xsd:string |
| http://purl.uniprot.org/citations/24394411 | http://purl.uniprot.org/core/author | "Gao W."xsd:string |
| http://purl.uniprot.org/citations/24394411 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/24394411 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/24394411 | http://purl.uniprot.org/core/author | "Li P."xsd:string |
| http://purl.uniprot.org/citations/24394411 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/24394411 | http://purl.uniprot.org/core/author | "Hou J."xsd:string |
| http://purl.uniprot.org/citations/24394411 | http://purl.uniprot.org/core/author | "Wong J."xsd:string |
| http://purl.uniprot.org/citations/24394411 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24394411 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/24394411 | http://purl.uniprot.org/core/pages | "5986-5996"xsd:string |
| http://purl.uniprot.org/citations/24394411 | http://purl.uniprot.org/core/title | "Differential regulation of the ten-eleven translocation (TET) family of dioxygenases by O-linked beta-N-acetylglucosamine transferase (OGT)."xsd:string |
| http://purl.uniprot.org/citations/24394411 | http://purl.uniprot.org/core/volume | "289"xsd:string |
| http://purl.uniprot.org/citations/24394411 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24394411 |
| http://purl.uniprot.org/citations/24394411 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24394411 |
| http://purl.uniprot.org/uniprot/#_A0A0B7MAW8-mappedCitation-24394411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24394411 |
| http://purl.uniprot.org/uniprot/#_A0A0B7MHT7-mappedCitation-24394411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24394411 |
| http://purl.uniprot.org/uniprot/#_A0A0B7MHU2-mappedCitation-24394411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24394411 |
| http://purl.uniprot.org/uniprot/#_A0A0B7MGW8-mappedCitation-24394411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24394411 |
| http://purl.uniprot.org/uniprot/#_A0A0B7MG67-mappedCitation-24394411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24394411 |
| http://purl.uniprot.org/uniprot/#_A7E237-mappedCitation-24394411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24394411 |
| http://purl.uniprot.org/uniprot/#_A0A158SIU0-mappedCitation-24394411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24394411 |
| http://purl.uniprot.org/uniprot/#_O43151-mappedCitation-24394411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24394411 |