| http://purl.uniprot.org/citations/24394666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24394666 | http://www.w3.org/2000/01/rdf-schema#comment | "We investigated adhesion pathways that contribute to engraftment of breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 (BCR-ABL1)-induced chronic myelogenous leukemia (CML)-like myeloproliferative neoplasia in a mouse retroviral transduction/transplantation model. Compared with normal stem/progenitor cells, BCR-ABL1(+) progenitors had similar expression of very late antigen-4 (VLA4), VLA5, leukocyte functional antigen-1, and CXCR4 but lower expression of P-selectin glycoprotein ligand-1 (PSGL-1) and of L-selectin. Whereas vascular cell adhesion molecule-1 and P-selectin were not required, deficiency of E-selectin in the recipient bone marrow endothelium significantly reduced engraftment by BCR-ABL1-expressing stem cells following intravenous injection, with leukemogenesis restored by direct intrafemoral injection. BCR-ABL1-expressing cells deficient for PSGL-1 or the selectin ligand-synthesizing enzymes core-2 β1,6-N-acetylglucosaminyltransferase or fucosyltransferases IV/VII were impaired for engraftment, and destruction of selectin ligands on leukemic progenitors by neuraminidase reduced engraftment. BCR-ABL1-expressing L-selectin-deficient progenitors were also defective in homing and engraftment, with leukemogenesis rescued by coexpression of chimeric E/L-selectin. Antibody to L-selectin decreased the engraftment of BCR-ABL1-transduced stem cells. These results establish that BCR-ABL1(+) leukemic stem cells rely to a greater extent on selectins and their ligands for homing and engraftment than do normal stem cells. Selectin blockade is a novel strategy to exploit differences between normal and leukemic stem cells that may be beneficial in autologous transplantation for CML and perhaps other leukemias."xsd:string |
| http://purl.uniprot.org/citations/24394666 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2013-11-538694"xsd:string |
| http://purl.uniprot.org/citations/24394666 | http://purl.uniprot.org/core/author | "Van Etten R.A."xsd:string |
| http://purl.uniprot.org/citations/24394666 | http://purl.uniprot.org/core/author | "Lewis J.B."xsd:string |
| http://purl.uniprot.org/citations/24394666 | http://purl.uniprot.org/core/author | "von Andrian U.H."xsd:string |
| http://purl.uniprot.org/citations/24394666 | http://purl.uniprot.org/core/author | "Krause D.S."xsd:string |
| http://purl.uniprot.org/citations/24394666 | http://purl.uniprot.org/core/author | "Lazarides K."xsd:string |
| http://purl.uniprot.org/citations/24394666 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24394666 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/24394666 | http://purl.uniprot.org/core/pages | "1361-1371"xsd:string |
| http://purl.uniprot.org/citations/24394666 | http://purl.uniprot.org/core/title | "Selectins and their ligands are required for homing and engraftment of BCR-ABL1+ leukemic stem cells in the bone marrow niche."xsd:string |
| http://purl.uniprot.org/citations/24394666 | http://purl.uniprot.org/core/volume | "123"xsd:string |
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