| http://purl.uniprot.org/citations/24395779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24395779 | http://www.w3.org/2000/01/rdf-schema#comment | "High fidelity homologous DNA recombination depends on mismatch repair (MMR), which antagonizes recombination between divergent sequences by rejecting heteroduplex DNA containing excessive nucleotide mismatches. The hMSH2-hMSH6 heterodimer is the first responder in postreplicative MMR and also plays a prominent role in heteroduplex rejection. Whether a similar molecular mechanism underlies its function in these two processes remains enigmatic. We have determined that hMSH2-hMSH6 efficiently recognizes mismatches within a D-loop recombination initiation intermediate. Mismatch recognition by hMSH2-hMSH6 is not abrogated by human replication protein A (HsRPA) bound to the displaced single-stranded DNA (ssDNA) or by HsRAD51. In addition, ATP-bound hMSH2-hMSH6 sliding clamps that are essential for downstream MMR processes are formed and constrained within the heteroduplex region of the D-loop. Moreover, the hMSH2-hMSH6 sliding clamps are stabilized on the D-loop by HsRPA bound to the displaced ssDNA. Our findings reveal similarities and differences in hMSH2-hMSH6 mismatch recognition and sliding-clamp formation between a D-loop recombination intermediate and linear duplex DNA."xsd:string |
| http://purl.uniprot.org/citations/24395779 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1312988111"xsd:string |
| http://purl.uniprot.org/citations/24395779 | http://purl.uniprot.org/core/author | "Honda M."xsd:string |
| http://purl.uniprot.org/citations/24395779 | http://purl.uniprot.org/core/author | "Okuno Y."xsd:string |
| http://purl.uniprot.org/citations/24395779 | http://purl.uniprot.org/core/author | "Spies M."xsd:string |
| http://purl.uniprot.org/citations/24395779 | http://purl.uniprot.org/core/author | "Fishel R."xsd:string |
| http://purl.uniprot.org/citations/24395779 | http://purl.uniprot.org/core/author | "Soukup R.J."xsd:string |
| http://purl.uniprot.org/citations/24395779 | http://purl.uniprot.org/core/author | "Amunugama R."xsd:string |
| http://purl.uniprot.org/citations/24395779 | http://purl.uniprot.org/core/author | "Subramanyam S."xsd:string |
| http://purl.uniprot.org/citations/24395779 | http://purl.uniprot.org/core/author | "Martin-Lopez J.V."xsd:string |
| http://purl.uniprot.org/citations/24395779 | http://purl.uniprot.org/core/author | "Hengel S.R."xsd:string |
| http://purl.uniprot.org/citations/24395779 | http://purl.uniprot.org/core/author | "Cook C.P."xsd:string |
| http://purl.uniprot.org/citations/24395779 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24395779 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/24395779 | http://purl.uniprot.org/core/pages | "E316-25"xsd:string |
| http://purl.uniprot.org/citations/24395779 | http://purl.uniprot.org/core/title | "Mismatch repair protein hMSH2-hMSH6 recognizes mismatches and forms sliding clamps within a D-loop recombination intermediate."xsd:string |
| http://purl.uniprot.org/citations/24395779 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/24395779 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24395779 |
| http://purl.uniprot.org/citations/24395779 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24395779 |
| http://purl.uniprot.org/uniprot/#_A0A2R8Y6P0-mappedCitation-24395779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24395779 |
| http://purl.uniprot.org/uniprot/#_P52701-mappedCitation-24395779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24395779 |
| http://purl.uniprot.org/uniprot/#_Q0ZAI9-mappedCitation-24395779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24395779 |
| http://purl.uniprot.org/uniprot/#_Q0ZAJ0-mappedCitation-24395779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24395779 |
| http://purl.uniprot.org/uniprot/#_A5JTV2-mappedCitation-24395779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24395779 |