| http://purl.uniprot.org/citations/24395802 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24395802 | http://www.w3.org/2000/01/rdf-schema#comment | "Chronic recurrent multifocal osteomyelitis (CRMO) is a human autoinflammatory disorder that primarily affects bone. Missense mutation (L98P) of proline-serine-threonine phosphatase-interacting protein 2 (Pstpip2) in mice leads to a disease that is phenotypically similar to CRMO called chronic multifocal osteomyelitis (cmo). Here we show that deficiency of IL-1RI in cmo mice resulted in a significant reduction in the time to onset of disease as well as the degree of bone pathology. Additionally, the proinflammatory cytokine IL-1β, but not IL-1α, played a critical role in the pathology observed in cmo mice. In contrast, disease in cmo mice was found to be independent of the nucleotide-binding domain, leucine-rich repeat-containing family, pyrin domain-containing 3 (NLRP3) inflammasome as well as caspase-1. Neutrophils, but not bone marrow-derived macrophages, from cmo mice secreted increased IL-1β in response to ATP, silica, and Pseudomonas aeruginosa compared with neutrophils from WT mice. This aberrant neutrophil response was sensitive to inhibition by serine protease inhibitors. These results demonstrate an inflammasome-independent role for IL-1β in disease progression of cmo and implicate neutrophils and neutrophil serine proteases in disease pathogenesis. These data provide a rationale for directly targeting IL-1RI or IL-1β as a therapeutic strategy in CRMO."xsd:string |
| http://purl.uniprot.org/citations/24395802 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1318685111"xsd:string |
| http://purl.uniprot.org/citations/24395802 | http://purl.uniprot.org/core/author | "Iwakura Y."xsd:string |
| http://purl.uniprot.org/citations/24395802 | http://purl.uniprot.org/core/author | "Bassuk A.G."xsd:string |
| http://purl.uniprot.org/citations/24395802 | http://purl.uniprot.org/core/author | "Brogden K.A."xsd:string |
| http://purl.uniprot.org/citations/24395802 | http://purl.uniprot.org/core/author | "Olivier A.K."xsd:string |
| http://purl.uniprot.org/citations/24395802 | http://purl.uniprot.org/core/author | "Sutterwala F.S."xsd:string |
| http://purl.uniprot.org/citations/24395802 | http://purl.uniprot.org/core/author | "Bing X."xsd:string |
| http://purl.uniprot.org/citations/24395802 | http://purl.uniprot.org/core/author | "Abu-Amer Y."xsd:string |
| http://purl.uniprot.org/citations/24395802 | http://purl.uniprot.org/core/author | "Ferguson P.J."xsd:string |
| http://purl.uniprot.org/citations/24395802 | http://purl.uniprot.org/core/author | "Shayakhmetov D.M."xsd:string |
| http://purl.uniprot.org/citations/24395802 | http://purl.uniprot.org/core/author | "Cassel S.L."xsd:string |
| http://purl.uniprot.org/citations/24395802 | http://purl.uniprot.org/core/author | "Burns T.L."xsd:string |
| http://purl.uniprot.org/citations/24395802 | http://purl.uniprot.org/core/author | "Wilson S.P."xsd:string |
| http://purl.uniprot.org/citations/24395802 | http://purl.uniprot.org/core/author | "Otero J.E."xsd:string |
| http://purl.uniprot.org/citations/24395802 | http://purl.uniprot.org/core/author | "Janczy J.R."xsd:string |
| http://purl.uniprot.org/citations/24395802 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24395802 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/24395802 | http://purl.uniprot.org/core/pages | "1072-1077"xsd:string |
| http://purl.uniprot.org/citations/24395802 | http://purl.uniprot.org/core/title | "Inflammasome-independent IL-1beta mediates autoinflammatory disease in Pstpip2-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/24395802 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/24395802 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24395802 |
| http://purl.uniprot.org/citations/24395802 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24395802 |
| http://purl.uniprot.org/uniprot/#_A0A571BDI1-mappedCitation-24395802 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24395802 |