| http://purl.uniprot.org/citations/24396066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24396066 | http://www.w3.org/2000/01/rdf-schema#comment | "The simultaneous interaction of poly(A)-binding protein (PABP) with eukaryotic translation initiation factor 4G (eIF4G) and the mRNA 3' poly(A) tail promotes translation initiation. We previously showed that the interaction of PABP-interacting protein 1 (Paip1) with PABP and eukaryotic translation initiation factor 3 (eIF3; via the eIF3g subunit) further stimulates translation. Here, we demonstrate that the interaction of eIF3 with Paip1 is regulated by amino acids through the mTORC1 signaling pathway. The Paip1-eIF3 interaction is impaired by the mTORC1 inhibitors, rapamycin and PP242. We show that ribosomal protein S6 kinases 1 and 2 (S6K1/2) promote the interaction of eIF3 with Paip1. The enhancement of Paip1-eIF3 interaction by amino acids is abrogated by an S6K inhibitor or shRNA against S6K1/2. S6K1 interacts with eIF3f and, in vitro, phosphorylates eIF3. Finally, we show that S6K inhibition leads to a reduction in translation by Paip1. We propose that S6K1/2 phosphorylate eIF3 to stimulate Paip1-eIF3 interaction and consequent translation initiation. Taken together, these data demonstrate that eIF3 is a new translation target of the mTOR/S6K pathway."xsd:string |
| http://purl.uniprot.org/citations/24396066 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01079-13"xsd:string |
| http://purl.uniprot.org/citations/24396066 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/24396066 | http://purl.uniprot.org/core/author | "Alain T."xsd:string |
| http://purl.uniprot.org/citations/24396066 | http://purl.uniprot.org/core/author | "Martineau Y."xsd:string |
| http://purl.uniprot.org/citations/24396066 | http://purl.uniprot.org/core/author | "Petroulakis E."xsd:string |
| http://purl.uniprot.org/citations/24396066 | http://purl.uniprot.org/core/author | "Sonenberg N."xsd:string |
| http://purl.uniprot.org/citations/24396066 | http://purl.uniprot.org/core/author | "Pyronnet S."xsd:string |
| http://purl.uniprot.org/citations/24396066 | http://purl.uniprot.org/core/author | "Monsarrat B."xsd:string |
| http://purl.uniprot.org/citations/24396066 | http://purl.uniprot.org/core/author | "Fabre B."xsd:string |
| http://purl.uniprot.org/citations/24396066 | http://purl.uniprot.org/core/author | "Shahbazian D."xsd:string |
| http://purl.uniprot.org/citations/24396066 | http://purl.uniprot.org/core/author | "Bousquet-Dubouch M.P."xsd:string |
| http://purl.uniprot.org/citations/24396066 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24396066 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/24396066 | http://purl.uniprot.org/core/pages | "1046-1053"xsd:string |
| http://purl.uniprot.org/citations/24396066 | http://purl.uniprot.org/core/title | "Control of Paip1-eukayrotic translation initiation factor 3 interaction by amino acids through S6 kinase."xsd:string |
| http://purl.uniprot.org/citations/24396066 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/24396066 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24396066 |
| http://purl.uniprot.org/citations/24396066 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24396066 |
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| http://purl.uniprot.org/uniprot/#_O00303-mappedCitation-24396066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24396066 |
| http://purl.uniprot.org/uniprot/#_P23116-mappedCitation-24396066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24396066 |
| http://purl.uniprot.org/uniprot/#_Q3B770-mappedCitation-24396066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24396066 |