| http://purl.uniprot.org/citations/24397609 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24397609 | http://www.w3.org/2000/01/rdf-schema#comment | "The CALM-AF10 fusion gene, which results from a t(10;11) translocation, is found in a variety of hematopoietic malignancies. Certain HOXA cluster genes and MEIS1 genes are upregulated in patients and mouse models that express CALM-AF10. Wild-type clathrin assembly lymphoid myeloid leukemia protein (CALM) primarily localizes in a diffuse pattern within the cytoplasm, whereas AF10 localizes in the nucleus; however, it is not clear where CALM-AF10 acts to induce leukemia. To investigate the influence of localization on leukemogenesis involving CALM-AF10, we determined the nuclear export signal (NES) within CALM that is necessary and sufficient for cytoplasmic localization of CALM-AF10. Mutations in the NES eliminated the capacity of CALM-AF10 to immortalize murine bone-marrow cells in vitro and to promote development of acute myeloid leukemia in mouse models. Furthermore, a fusion of AF10 with the minimal NES can immortalize bone-marrow cells and induce leukemia in mice. These results suggest that during leukemogenesis, CALM-AF10 plays its critical roles in the cytoplasm."xsd:string |
| http://purl.uniprot.org/citations/24397609 | http://purl.org/dc/terms/identifier | "doi:10.1111/cas.12347"xsd:string |
| http://purl.uniprot.org/citations/24397609 | http://purl.uniprot.org/core/author | "Suzuki M."xsd:string |
| http://purl.uniprot.org/citations/24397609 | http://purl.uniprot.org/core/author | "Watanabe T."xsd:string |
| http://purl.uniprot.org/citations/24397609 | http://purl.uniprot.org/core/author | "Yamagata K."xsd:string |
| http://purl.uniprot.org/citations/24397609 | http://purl.uniprot.org/core/author | "Akashi K."xsd:string |
| http://purl.uniprot.org/citations/24397609 | http://purl.uniprot.org/core/author | "Aikawa Y."xsd:string |
| http://purl.uniprot.org/citations/24397609 | http://purl.uniprot.org/core/author | "Kitabayashi I."xsd:string |
| http://purl.uniprot.org/citations/24397609 | http://purl.uniprot.org/core/author | "Shino M."xsd:string |
| http://purl.uniprot.org/citations/24397609 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24397609 | http://purl.uniprot.org/core/name | "Cancer Sci"xsd:string |
| http://purl.uniprot.org/citations/24397609 | http://purl.uniprot.org/core/pages | "315-323"xsd:string |
| http://purl.uniprot.org/citations/24397609 | http://purl.uniprot.org/core/title | "Nuclear export signal within CALM is necessary for CALM-AF10-induced leukemia."xsd:string |
| http://purl.uniprot.org/citations/24397609 | http://purl.uniprot.org/core/volume | "105"xsd:string |
| http://purl.uniprot.org/citations/24397609 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24397609 |
| http://purl.uniprot.org/citations/24397609 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24397609 |
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