| http://purl.uniprot.org/citations/24399721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24399721 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundThis study examined the significant association between carbamazepine (CBZ)-induced Stevens-Johnson Syndrome (SJS)/toxic epidermal necrolysis (TEN) and HLA-B*15:02 in epilepsy patients of Han ethnicity living in northeastern China.MethodsCBZ-SJS/TEN patients and CBZ-tolerant control patients were genotyped for HLA-B*15:02 by PCR amplification using sequence-specific primers. Patients then were evaluated for HLA genotypes using PCR with sequence-based typing.ResultsEight of 35 CBZ-SJS/TEN patients carried HLA-B*15:02 (22.9%) versus 2 of 125 in CBZ-tolerant control patients (OR = 18.222, 95% CI = 3.662-90.662, p = 0.000). Our results suggest that HLA-B*15:02 is necessary but is not sufficient to produce SJS/TEN following CBZ treatment among Han individuals from northeastern China. Other HLA alleles, including A*33:03, B*58:01, C*03:02, DQB1*03:03, and DRB1*07:01 may be associated weakly with CBZ-SJS/TEN.ConclusionsOur results are not consistent with previous studies reporting a strong association between HLA-B*15:02 and CBZ-SJS/TEN among individuals from southern, southwestern, and central China. Other genes may be more tightly associated with CBZ-SJS/TEN. Screening for HLA-B*15:02 still may be recommended for patients in northeastern China before starting CBZ."xsd:string |
| http://purl.uniprot.org/citations/24399721 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1734-1140(13)71483-x"xsd:string |
| http://purl.uniprot.org/citations/24399721 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/24399721 | http://purl.uniprot.org/core/author | "Xu Y.Y."xsd:string |
| http://purl.uniprot.org/citations/24399721 | http://purl.uniprot.org/core/author | "He X.J."xsd:string |
| http://purl.uniprot.org/citations/24399721 | http://purl.uniprot.org/core/author | "Sun X.J."xsd:string |
| http://purl.uniprot.org/citations/24399721 | http://purl.uniprot.org/core/author | "He X.L."xsd:string |
| http://purl.uniprot.org/citations/24399721 | http://purl.uniprot.org/core/author | "Zhao L.M."xsd:string |
| http://purl.uniprot.org/citations/24399721 | http://purl.uniprot.org/core/author | "Miao L.Y."xsd:string |
| http://purl.uniprot.org/citations/24399721 | http://purl.uniprot.org/core/author | "Jian L.Y."xsd:string |
| http://purl.uniprot.org/citations/24399721 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24399721 | http://purl.uniprot.org/core/name | "Pharmacol Rep"xsd:string |
| http://purl.uniprot.org/citations/24399721 | http://purl.uniprot.org/core/pages | "1256-1262"xsd:string |
| http://purl.uniprot.org/citations/24399721 | http://purl.uniprot.org/core/title | "Association between the HLA-B*15:02 allele and carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Han individuals of northeastern China."xsd:string |
| http://purl.uniprot.org/citations/24399721 | http://purl.uniprot.org/core/volume | "65"xsd:string |
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