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http://purl.uniprot.org/citations/24405067http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24405067http://www.w3.org/2000/01/rdf-schema#comment"

Object

Variants of Kallikreins have been shown to be risk factors for intracranial aneurysm (IA) in a Finnish population. In the present study, the authors investigated the correlation between polymorphisms in the Kallikrein gene cluster and IAs in the Chinese population.

Methods

The association of Kallikrein variants (rs1722561 and rs1701946) with sporadic IAs was tested in 308 cases and 443 controls. The differences in allelic frequencies between patients and the control group were evaluated with the chi-square test.

Results

The C allele of rs1722561 showed a significant reduction in the risk of sporadic IA (OR 0.71, 95% CI 0.53-0.95; p = 0.023). However, no association of the variant rs1701946 with sporadic IA was found (OR 0.78, 95% CI 0.57-1.06; p = 0.115).

Conclusions

The variant rs1722561 of Kallikreins might reduce the risk of sporadic IAs among individuals of Chinese Han ethnicity. This study confirms the association between Kallikreins and IAs."xsd:string
http://purl.uniprot.org/citations/24405067http://purl.org/dc/terms/identifier"doi:10.3171/2013.11.jns131036"xsd:string
http://purl.uniprot.org/citations/24405067http://purl.uniprot.org/core/author"Chen J."xsd:string
http://purl.uniprot.org/citations/24405067http://purl.uniprot.org/core/author"Lin Y."xsd:string
http://purl.uniprot.org/citations/24405067http://purl.uniprot.org/core/author"Song Y."xsd:string
http://purl.uniprot.org/citations/24405067http://purl.uniprot.org/core/author"Song W."xsd:string
http://purl.uniprot.org/citations/24405067http://purl.uniprot.org/core/author"Zhang Y."xsd:string
http://purl.uniprot.org/citations/24405067http://purl.uniprot.org/core/author"Zhang C."xsd:string
http://purl.uniprot.org/citations/24405067http://purl.uniprot.org/core/author"Yu H."xsd:string
http://purl.uniprot.org/citations/24405067http://purl.uniprot.org/core/author"Zhu Y."xsd:string
http://purl.uniprot.org/citations/24405067http://purl.uniprot.org/core/author"Hui R."xsd:string
http://purl.uniprot.org/citations/24405067http://purl.uniprot.org/core/author"Pang Q."xsd:string
http://purl.uniprot.org/citations/24405067http://purl.uniprot.org/core/author"Sun K."xsd:string
http://purl.uniprot.org/citations/24405067http://purl.uniprot.org/core/author"Suo M."xsd:string
http://purl.uniprot.org/citations/24405067http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/24405067http://purl.uniprot.org/core/name"J Neurosurg"xsd:string
http://purl.uniprot.org/citations/24405067http://purl.uniprot.org/core/pages"1397-1401"xsd:string
http://purl.uniprot.org/citations/24405067http://purl.uniprot.org/core/title"Association of Kallikrein gene polymorphisms with sporadic intracranial aneurysms in the Chinese population."xsd:string
http://purl.uniprot.org/citations/24405067http://purl.uniprot.org/core/volume"120"xsd:string
http://purl.uniprot.org/citations/24405067http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/24405067
http://purl.uniprot.org/citations/24405067http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/24405067
http://purl.uniprot.org/uniprot/#_A0A0C4DFQ5-mappedCitation-24405067http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24405067
http://purl.uniprot.org/uniprot/#_B1GRN1-mappedCitation-24405067http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24405067
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