| http://purl.uniprot.org/citations/24407558 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24407558 | http://www.w3.org/2000/01/rdf-schema#comment | "LMO2 was discovered via chromosomal translocations in T-cell leukaemia and shown normally to be essential for haematopoiesis. LMO2 is made up of two LIM only domains (thus it is a LIM-only protein) and forms a bridge in a multi-protein complex. We have studied the mechanism of formation of this complex using a single domain antibody fragment that inhibits LMO2 by sequestering it in a non-functional form. The crystal structure of LMO2 with this antibody fragment has been solved revealing a conformational difference in the positioning and angle between the two LIM domains compared with its normal binding. This contortion occurs by bending at a central helical region of LMO2. This is a unique mechanism for inhibiting an intracellular protein function and the structural contusion implies a model in which newly synthesized, intrinsically disordered LMO2 binds to a partner protein nucleating further interactions and suggests approaches for therapeutic targeting of LMO2."xsd:string |
| http://purl.uniprot.org/citations/24407558 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep03643"xsd:string |
| http://purl.uniprot.org/citations/24407558 | http://purl.uniprot.org/core/author | "Tanaka T."xsd:string |
| http://purl.uniprot.org/citations/24407558 | http://purl.uniprot.org/core/author | "Chambers J."xsd:string |
| http://purl.uniprot.org/citations/24407558 | http://purl.uniprot.org/core/author | "El Omari K."xsd:string |
| http://purl.uniprot.org/citations/24407558 | http://purl.uniprot.org/core/author | "Mancini E.J."xsd:string |
| http://purl.uniprot.org/citations/24407558 | http://purl.uniprot.org/core/author | "Fernandez-Fuentes N."xsd:string |
| http://purl.uniprot.org/citations/24407558 | http://purl.uniprot.org/core/author | "Rabbitts T.H."xsd:string |
| http://purl.uniprot.org/citations/24407558 | http://purl.uniprot.org/core/author | "Cruz A."xsd:string |
| http://purl.uniprot.org/citations/24407558 | http://purl.uniprot.org/core/author | "Sewell H."xsd:string |
| http://purl.uniprot.org/citations/24407558 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24407558 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/24407558 | http://purl.uniprot.org/core/pages | "3643"xsd:string |
| http://purl.uniprot.org/citations/24407558 | http://purl.uniprot.org/core/title | "Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex."xsd:string |
| http://purl.uniprot.org/citations/24407558 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/24407558 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24407558 |
| http://purl.uniprot.org/citations/24407558 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24407558 |
| http://purl.uniprot.org/uniprot/#_P01764-mappedCitation-24407558 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24407558 |
| http://purl.uniprot.org/uniprot/#_P25791-mappedCitation-24407558 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24407558 |
| http://purl.uniprot.org/uniprot/P01764 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24407558 |
| http://purl.uniprot.org/uniprot/P25791 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24407558 |