http://purl.uniprot.org/citations/24408320 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/24408320 | http://www.w3.org/2000/01/rdf-schema#comment | "In subjects mismatched in the HLA alleles C*03:03/C*03:04 no allogeneic cytotoxic T-lymphocyte responses are detected in vitro. Hematopoietic stem cell transplantation (HSCT) with unrelated donors (UDs) showed no association between the HLA-C allele mismatches (CAMMs) and adverse outcomes; antigen mismatches at this and mismatches other HLA loci are deleterious. The absence of effect of the CAMM may have resulted from the predominance of the mismatch C*03:03/C*03:04. Patients with hematologic malignancies receiving UD HSCT matched in 8/8 and 7/8 HLA alleles were examined. Transplants mismatched in HLA-C antigens or mismatched in HLA-A, -B, or -DRB1 presented significant differences (P < .0001) in mortality (hazard ratio [HR] = 1.37, 1.30), disease-free survival (HR = 1.33, 1.27), treatment-related mortality (HR = 1.54, 1.54), and grade 3-4 acute graft-versus-host disease (HR = 1.49, 1.77) compared with the 8/8 group; transplants mismatched in other CAMMs had similar outcomes with HR ranging from 1.34 to 172 for these endpoints. The C*03:03/C*03:04 mismatched and the 8/8 matched groups had identical outcomes (HR ranging from 0.96-1.05). The previous finding that CAMMs do not associate with adverse outcomes is explained by the predominance (69%) of the mismatch C*03:03/03:04 in this group that is better tolerated than other HLA mismatches."xsd:string |
http://purl.uniprot.org/citations/24408320 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2013-10-532671"xsd:string |
http://purl.uniprot.org/citations/24408320 | http://purl.uniprot.org/core/author | "Lee S.J."xsd:string |
http://purl.uniprot.org/citations/24408320 | http://purl.uniprot.org/core/author | "Wang T."xsd:string |
http://purl.uniprot.org/citations/24408320 | http://purl.uniprot.org/core/author | "Marino S."xsd:string |
http://purl.uniprot.org/citations/24408320 | http://purl.uniprot.org/core/author | "Baxter-Lowe L.A."xsd:string |
http://purl.uniprot.org/citations/24408320 | http://purl.uniprot.org/core/author | "Schultz K."xsd:string |
http://purl.uniprot.org/citations/24408320 | http://purl.uniprot.org/core/author | "Aljurf M."xsd:string |
http://purl.uniprot.org/citations/24408320 | http://purl.uniprot.org/core/author | "Fernandez-Vina M.A."xsd:string |
http://purl.uniprot.org/citations/24408320 | http://purl.uniprot.org/core/author | "Marsh S.G."xsd:string |
http://purl.uniprot.org/citations/24408320 | http://purl.uniprot.org/core/author | "Petersdorf E.W."xsd:string |
http://purl.uniprot.org/citations/24408320 | http://purl.uniprot.org/core/author | "Setterholm M."xsd:string |
http://purl.uniprot.org/citations/24408320 | http://purl.uniprot.org/core/author | "Waller E.K."xsd:string |
http://purl.uniprot.org/citations/24408320 | http://purl.uniprot.org/core/author | "Oudshoorn M."xsd:string |
http://purl.uniprot.org/citations/24408320 | http://purl.uniprot.org/core/author | "Askar M."xsd:string |
http://purl.uniprot.org/citations/24408320 | http://purl.uniprot.org/core/author | "Woolfrey A."xsd:string |
http://purl.uniprot.org/citations/24408320 | http://purl.uniprot.org/core/author | "Haagenson M."xsd:string |
http://purl.uniprot.org/citations/24408320 | http://purl.uniprot.org/core/author | "Spellman S.R."xsd:string |
http://purl.uniprot.org/citations/24408320 | http://purl.uniprot.org/core/author | "Battiwalla M."xsd:string |
http://purl.uniprot.org/citations/24408320 | http://purl.uniprot.org/core/author | "Gajewski J."xsd:string |
http://purl.uniprot.org/citations/24408320 | http://purl.uniprot.org/core/author | "Jakubowski A.A."xsd:string |
http://purl.uniprot.org/citations/24408320 | http://purl.uniprot.org/core/author | "Turner E.V."xsd:string |
http://purl.uniprot.org/citations/24408320 | http://purl.uniprot.org/core/author | "Umejiego J."xsd:string |
http://purl.uniprot.org/citations/24408320 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |