| http://purl.uniprot.org/citations/24419084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24419084 | http://www.w3.org/2000/01/rdf-schema#comment | "Hyperactive β-catenin drives colorectal cancer, yet inhibiting its activity remains a formidable challenge. Interest is mounting in tankyrase inhibitors (TNKSi), which destabilize β-catenin through stabilizing Axin. Here, we confirm that TNKSi inhibit Wnt-induced transcription, similarly to carnosate, which reduces the transcriptional activity of β-catenin by blocking its binding to BCL9, and attenuates intestinal tumors in Apc(Min) mice. By contrast, β-catenin's activity is unresponsive to TNKSi in colorectal cancer cells and in cells after prolonged Wnt stimulation. This TNKSi insensitivity is conferred by β-catenin's association with LEF1 and BCL9-2/B9L, which accumulate during Wnt stimulation, thereby providing a feed-forward loop that converts transient into chronic β-catenin signaling. This limits the therapeutic value of TNKSi in colorectal carcinomas, most of which express high LEF1 levels. Our study provides proof-of-concept that the successful inhibition of oncogenic β-catenin in colorectal cancer requires the targeting of its interaction with LEF1 and/or BCL9/B9L, as exemplified by carnosate."xsd:string |
| http://purl.uniprot.org/citations/24419084 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-13-2682"xsd:string |
| http://purl.uniprot.org/citations/24419084 | http://purl.uniprot.org/core/author | "Bienz M."xsd:string |
| http://purl.uniprot.org/citations/24419084 | http://purl.uniprot.org/core/author | "de la Roche M."xsd:string |
| http://purl.uniprot.org/citations/24419084 | http://purl.uniprot.org/core/author | "Mieszczanek J."xsd:string |
| http://purl.uniprot.org/citations/24419084 | http://purl.uniprot.org/core/author | "Ibrahim A.E."xsd:string |
| http://purl.uniprot.org/citations/24419084 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24419084 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/24419084 | http://purl.uniprot.org/core/pages | "1495-1505"xsd:string |
| http://purl.uniprot.org/citations/24419084 | http://purl.uniprot.org/core/title | "LEF1 and B9L shield beta-catenin from inactivation by Axin, desensitizing colorectal cancer cells to tankyrase inhibitors."xsd:string |
| http://purl.uniprot.org/citations/24419084 | http://purl.uniprot.org/core/volume | "74"xsd:string |
| http://purl.uniprot.org/citations/24419084 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24419084 |
| http://purl.uniprot.org/citations/24419084 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24419084 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4R0-mappedCitation-24419084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24419084 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4S3-mappedCitation-24419084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24419084 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DGE3-mappedCitation-24419084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24419084 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4M1-mappedCitation-24419084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24419084 |
| http://purl.uniprot.org/uniprot/#_B2RUG9-mappedCitation-24419084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24419084 |
| http://purl.uniprot.org/uniprot/#_B4DYP4-mappedCitation-24419084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24419084 |
| http://purl.uniprot.org/uniprot/#_B4DX38-mappedCitation-24419084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24419084 |
| http://purl.uniprot.org/uniprot/#_B4DXL6-mappedCitation-24419084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24419084 |
| http://purl.uniprot.org/uniprot/#_B4DZY5-mappedCitation-24419084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24419084 |
| http://purl.uniprot.org/uniprot/#_E9QLQ9-mappedCitation-24419084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24419084 |
| http://purl.uniprot.org/uniprot/#_F6Z405-mappedCitation-24419084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24419084 |