| http://purl.uniprot.org/citations/24421385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24421385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24421385 | http://www.w3.org/2000/01/rdf-schema#comment | "Abcb10, member 10 of the ABC transporter family, is reportedly a part of a complex in the mitochondrial inner membrane with mitoferrin-1 (Slc25a37) and ferrochelatase (Fech) and is responsible for heme biosynthesis in utero. However, it is unclear whether loss of Abcb10 causes pathological changes in adult mice. Here, we show that Abcb10(-/-) mice lack heme biosynthesis and erythropoiesis abilities and die in midgestation. Moreover, we generated Abcb10(F/-); Mx1-Cre mice, with Abcb10 in hematopoietic cells deleted, which showed accumulation of protoporphyrin IX and maturation arrest in reticulocytes. Electron microscopy images of Abcb10(-/-) hematopoietic cells showed a marked increase of iron deposits at the mitochondria. These results suggest a critical role for Abcb10 in heme biosynthesis and provide new insights into the pathogenesis of erythropoietic protoporphyria and sideroblastic anemia."xsd:string |
| http://purl.uniprot.org/citations/24421385 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00865-13"xsd:string |
| http://purl.uniprot.org/citations/24421385 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00865-13"xsd:string |
| http://purl.uniprot.org/citations/24421385 | http://purl.uniprot.org/core/author | "Nakagawa M."xsd:string |
| http://purl.uniprot.org/citations/24421385 | http://purl.uniprot.org/core/author | "Nakagawa M."xsd:string |
| http://purl.uniprot.org/citations/24421385 | http://purl.uniprot.org/core/author | "Minami K."xsd:string |
| http://purl.uniprot.org/citations/24421385 | http://purl.uniprot.org/core/author | "Minami K."xsd:string |
| http://purl.uniprot.org/citations/24421385 | http://purl.uniprot.org/core/author | "Yamamoto M."xsd:string |
| http://purl.uniprot.org/citations/24421385 | http://purl.uniprot.org/core/author | "Yamamoto M."xsd:string |
| http://purl.uniprot.org/citations/24421385 | http://purl.uniprot.org/core/author | "Nishizawa Y."xsd:string |
| http://purl.uniprot.org/citations/24421385 | http://purl.uniprot.org/core/author | "Nishizawa Y."xsd:string |
| http://purl.uniprot.org/citations/24421385 | http://purl.uniprot.org/core/author | "Akiyama S."xsd:string |
| http://purl.uniprot.org/citations/24421385 | http://purl.uniprot.org/core/author | "Akiyama S."xsd:string |
| http://purl.uniprot.org/citations/24421385 | http://purl.uniprot.org/core/author | "Arimura H."xsd:string |
| http://purl.uniprot.org/citations/24421385 | http://purl.uniprot.org/core/author | "Arimura H."xsd:string |
| http://purl.uniprot.org/citations/24421385 | http://purl.uniprot.org/core/author | "Fukushige T."xsd:string |
| http://purl.uniprot.org/citations/24421385 | http://purl.uniprot.org/core/author | "Fukushige T."xsd:string |
| http://purl.uniprot.org/citations/24421385 | http://purl.uniprot.org/core/author | "Furukawa T."xsd:string |
| http://purl.uniprot.org/citations/24421385 | http://purl.uniprot.org/core/author | "Furukawa T."xsd:string |
| http://purl.uniprot.org/citations/24421385 | http://purl.uniprot.org/core/author | "Kanekura T."xsd:string |
| http://purl.uniprot.org/citations/24421385 | http://purl.uniprot.org/core/author | "Kanekura T."xsd:string |
| http://purl.uniprot.org/citations/24421385 | http://purl.uniprot.org/core/author | "Tanimoto A."xsd:string |
| http://purl.uniprot.org/citations/24421385 | http://purl.uniprot.org/core/author | "Tanimoto A."xsd:string |