| http://purl.uniprot.org/citations/24431009 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24431009 | http://www.w3.org/2000/01/rdf-schema#comment | "We have conducted biochemical studies with commercial available pyrroline-5-carboxylate (P5C) reductase (PYCR1) to investigate whether this enzyme plays a role in L-lysine degradation. Our recent studies with antiquitin/ALDH7A1 deficient fibroblasts revealed an alternative genesis of L-pipecolic acid, and we then hypothesized that PYCR1 was responsible for the conversion of Δ(1)-piperideine-6-carboxylate (P6C) into pipecolic acid. We here present evidence that PYCR1 is indeed able to produce L-pipecolic acid from P6C preparations, and the observed K m for this conversion is of the same magnitude as the K m described for the conversion of P5C to L-proline by PYCR1. Urine samples from antiquitin deficient individuals, who accumulate P6C, were also incubated with PYCR1 which resulted in a marked decrease of P6C and a huge increase of L-pipecolic acid as measured by LC-MS/MS, confirming that indeed PYCR1 generates L-pipecolic acid from P6C."xsd:string |
| http://purl.uniprot.org/citations/24431009 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10545-013-9673-4"xsd:string |
| http://purl.uniprot.org/citations/24431009 | http://purl.uniprot.org/core/author | "Salomons G.S."xsd:string |
| http://purl.uniprot.org/citations/24431009 | http://purl.uniprot.org/core/author | "Jansen E.E."xsd:string |
| http://purl.uniprot.org/citations/24431009 | http://purl.uniprot.org/core/author | "Struys E.A."xsd:string |
| http://purl.uniprot.org/citations/24431009 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24431009 | http://purl.uniprot.org/core/name | "J Inherit Metab Dis"xsd:string |
| http://purl.uniprot.org/citations/24431009 | http://purl.uniprot.org/core/pages | "327-332"xsd:string |
| http://purl.uniprot.org/citations/24431009 | http://purl.uniprot.org/core/title | "Human pyrroline-5-carboxylate reductase (PYCR1) acts on Delta(1)-piperideine-6-carboxylate generating L-pipecolic acid."xsd:string |
| http://purl.uniprot.org/citations/24431009 | http://purl.uniprot.org/core/volume | "37"xsd:string |
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