| http://purl.uniprot.org/citations/24434213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24434213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24434213 | http://www.w3.org/2000/01/rdf-schema#comment | "Current antiangiogenic therapy is limited by its cytostatic nature and systemic side effects. To address these limitations, we have unveiled the role of RhoJ, an endothelial-enriched Rho GTPase, during tumor progression. RhoJ blockade provides a double assault on tumor vessels by both inhibiting tumor angiogenesis and disrupting the preformed tumor vessels through the activation of the RhoA-ROCK (Rho kinase) signaling pathway in tumor endothelial cells, consequently resulting in a functional failure of tumor vasculatures. Moreover, enhanced anticancer effects were observed when RhoJ blockade was employed in concert with a cytotoxic chemotherapeutic agent, angiogenesis-inhibiting agent, or vascular-disrupting agent. These results identify RhoJ blockade as a selective and effective therapeutic strategy for targeting tumor vasculature with minimal side effects."xsd:string |
| http://purl.uniprot.org/citations/24434213 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2013.12.010"xsd:string |
| http://purl.uniprot.org/citations/24434213 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2013.12.010"xsd:string |
| http://purl.uniprot.org/citations/24434213 | http://purl.uniprot.org/core/author | "Lee D."xsd:string |
| http://purl.uniprot.org/citations/24434213 | http://purl.uniprot.org/core/author | "Lee D."xsd:string |
| http://purl.uniprot.org/citations/24434213 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/24434213 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/24434213 | http://purl.uniprot.org/core/author | "Kataoka H."xsd:string |
| http://purl.uniprot.org/citations/24434213 | http://purl.uniprot.org/core/author | "Kataoka H."xsd:string |
| http://purl.uniprot.org/citations/24434213 | http://purl.uniprot.org/core/author | "Nishikawa S."xsd:string |
| http://purl.uniprot.org/citations/24434213 | http://purl.uniprot.org/core/author | "Nishikawa S."xsd:string |
| http://purl.uniprot.org/citations/24434213 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/24434213 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/24434213 | http://purl.uniprot.org/core/author | "Kim C."xsd:string |
| http://purl.uniprot.org/citations/24434213 | http://purl.uniprot.org/core/author | "Kim C."xsd:string |
| http://purl.uniprot.org/citations/24434213 | http://purl.uniprot.org/core/author | "Park J.S."xsd:string |
| http://purl.uniprot.org/citations/24434213 | http://purl.uniprot.org/core/author | "Park J.S."xsd:string |
| http://purl.uniprot.org/citations/24434213 | http://purl.uniprot.org/core/author | "Jung J."xsd:string |
| http://purl.uniprot.org/citations/24434213 | http://purl.uniprot.org/core/author | "Jung J."xsd:string |
| http://purl.uniprot.org/citations/24434213 | http://purl.uniprot.org/core/author | "Park I."xsd:string |
| http://purl.uniprot.org/citations/24434213 | http://purl.uniprot.org/core/author | "Park I."xsd:string |
| http://purl.uniprot.org/citations/24434213 | http://purl.uniprot.org/core/author | "Kim I."xsd:string |
| http://purl.uniprot.org/citations/24434213 | http://purl.uniprot.org/core/author | "Kim I."xsd:string |