| http://purl.uniprot.org/citations/24436419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24436419 | http://www.w3.org/2000/01/rdf-schema#comment | "Btk29A is the Drosophila ortholog of the mammalian Bruton's tyrosine kinase (Btk), mutations of which in humans cause a heritable immunodeficiency disease. Btk29A mutations stabilized the proliferating cystoblast fate, leading to an ovarian tumor. This phenotype was rescued by overexpression of wild-type Btk29A and phenocopied by the interference of Wnt4-β-catenin signaling or its putative downstream nuclear protein Piwi in somatic escort cells. Btk29A and mammalian Btk directly phosphorylated tyrosine residues of β-catenin, leading to the up-regulation of its transcriptional activity. Thus, we identify a transcriptional switch involving the kinase Btk29A/Btk and its phosphorylation target, β-catenin, which functions downstream of Wnt4 in escort cells to terminate Drosophila germ cell proliferation through up-regulation of piwi expression. This signaling mechanism likely represents a versatile developmental switch."xsd:string |
| http://purl.uniprot.org/citations/24436419 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1244512"xsd:string |
| http://purl.uniprot.org/citations/24436419 | http://purl.uniprot.org/core/author | "Smith C.I."xsd:string |
| http://purl.uniprot.org/citations/24436419 | http://purl.uniprot.org/core/author | "Yamamoto D."xsd:string |
| http://purl.uniprot.org/citations/24436419 | http://purl.uniprot.org/core/author | "Nore B.F."xsd:string |
| http://purl.uniprot.org/citations/24436419 | http://purl.uniprot.org/core/author | "Kuwada Y."xsd:string |
| http://purl.uniprot.org/citations/24436419 | http://purl.uniprot.org/core/author | "Hamada-Kawaguchi N."xsd:string |
| http://purl.uniprot.org/citations/24436419 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24436419 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/24436419 | http://purl.uniprot.org/core/pages | "294-297"xsd:string |
| http://purl.uniprot.org/citations/24436419 | http://purl.uniprot.org/core/title | "Btk29A promotes Wnt4 signaling in the niche to terminate germ cell proliferation in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/24436419 | http://purl.uniprot.org/core/volume | "343"xsd:string |
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