| http://purl.uniprot.org/citations/2443973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2443973 | http://www.w3.org/2000/01/rdf-schema#comment | "A group of proteins anchored to the cell by phosphatidylinositol (PI) has recently been identified. The significance of this new class of membrane anchor is unknown; one possibility is that it facilitates release of the molecule by phospholipases. In fact, phospholipase C enzymes specific for the complex carboxyl-terminal glycolipids of these proteins have been isolated from African trypanosomes and from hepatocyte plasma membranes. This study reports the discovery of a glycan-PI-specific phospholipase D in human serum that cleaves both the membrane form of the variant surface glycoprotein of African trypanosomes and its glycolipid precursor, but not phosphatidylethanolamine, phosphatidylcholine, or phosphatidylinositol. Decay-accelerating factor, another PI-anchored molecule, is also cleaved by the enzyme and converted from a hydrophobic to a soluble protein. The enzyme is Ca2+-dependent, heat labile, and not affected by the inhibitor of serine proteases, phenylmethylsulfonylfluoride. Its function is not known, but the present findings indicate that it participates in the metabolism of glycolipid-anchored membrane proteins."xsd:string |
| http://purl.uniprot.org/citations/2443973 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.2443973"xsd:string |
| http://purl.uniprot.org/citations/2443973 | http://purl.uniprot.org/core/author | "Hereld D."xsd:string |
| http://purl.uniprot.org/citations/2443973 | http://purl.uniprot.org/core/author | "Englund P.T."xsd:string |
| http://purl.uniprot.org/citations/2443973 | http://purl.uniprot.org/core/author | "Nussenzweig V."xsd:string |
| http://purl.uniprot.org/citations/2443973 | http://purl.uniprot.org/core/author | "Davitz M.A."xsd:string |
| http://purl.uniprot.org/citations/2443973 | http://purl.uniprot.org/core/author | "Shak S."xsd:string |
| http://purl.uniprot.org/citations/2443973 | http://purl.uniprot.org/core/author | "Krakow J."xsd:string |
| http://purl.uniprot.org/citations/2443973 | http://purl.uniprot.org/core/date | "1987"xsd:gYear |
| http://purl.uniprot.org/citations/2443973 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/2443973 | http://purl.uniprot.org/core/pages | "81-84"xsd:string |
| http://purl.uniprot.org/citations/2443973 | http://purl.uniprot.org/core/title | "A glycan-phosphatidylinositol-specific phospholipase D in human serum."xsd:string |
| http://purl.uniprot.org/citations/2443973 | http://purl.uniprot.org/core/volume | "238"xsd:string |
| http://purl.uniprot.org/citations/2443973 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2443973 |
| http://purl.uniprot.org/citations/2443973 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/2443973 |
| http://purl.uniprot.org/uniprot/#_Q14210-mappedCitation-2443973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2443973 |
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| http://purl.uniprot.org/uniprot/#_P04216-mappedCitation-2443973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2443973 |
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| http://purl.uniprot.org/uniprot/#_O95497-mappedCitation-2443973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2443973 |
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