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http://purl.uniprot.org/citations/24440566http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24440566http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Soluble fms-like tyrosine kinase (sFlt-1) is an important mediator in the pathogenesis of preeclampsia. We sought to determine whether platelet-monocyte aggregates (PMAs) produced sFlt-1 and whether PMAs contributed to sFlt-1 production in preeclampsia.

Study design

This was a case-control study of sFlt-1 release from PMAs using blood samples from women with preeclampsia matched by gestational age to pregnant controls. A third group of nonpregnant, reproductive-age women comprised an additional control group. Experiments were also performed using blood from nonpregnant women to elucidate whether inducing PMAs could stimulate sFlt-1 production and, if so, to determine the necessary receptors and pathways.

Results

Women with preeclampsia had increased total Flt-1 concentrations in platelets and monocytes at baseline compared with pregnant controls (25 vs 10 pg/mL, P = .0003). sFlt-1 production was elicited from monocytes incubated with thrombin-activated platelets from nonpregnant women. sFlt-1 production was regulated at the transcriptional level by p38 and nuclear factor-κB-dependent pathways.

Conclusion

Activated platelets in preeclampsia bind monocytes to generate sFlt-1. PMAs are a previously unrecognized source of sFlt-1 that may contribute to endothelial dysfunction and systemic inflammation commonly observed in preeclampsia."xsd:string
http://purl.uniprot.org/citations/24440566http://purl.org/dc/terms/identifier"doi:10.1016/j.ajog.2014.01.024"xsd:string
http://purl.uniprot.org/citations/24440566http://purl.uniprot.org/core/author"Weyrich A.S."xsd:string
http://purl.uniprot.org/citations/24440566http://purl.uniprot.org/core/author"Campbell R.A."xsd:string
http://purl.uniprot.org/citations/24440566http://purl.uniprot.org/core/author"Branch D.W."xsd:string
http://purl.uniprot.org/citations/24440566http://purl.uniprot.org/core/author"Silver R.M."xsd:string
http://purl.uniprot.org/citations/24440566http://purl.uniprot.org/core/author"Major H.D."xsd:string
http://purl.uniprot.org/citations/24440566http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/24440566http://purl.uniprot.org/core/name"Am J Obstet Gynecol"xsd:string
http://purl.uniprot.org/citations/24440566http://purl.uniprot.org/core/pages"547.e1-7"xsd:string
http://purl.uniprot.org/citations/24440566http://purl.uniprot.org/core/title"Synthesis of sFlt-1 by platelet-monocyte aggregates contributes to the pathogenesis of preeclampsia."xsd:string
http://purl.uniprot.org/citations/24440566http://purl.uniprot.org/core/volume"210"xsd:string
http://purl.uniprot.org/citations/24440566http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/24440566
http://purl.uniprot.org/citations/24440566http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/24440566
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