| http://purl.uniprot.org/citations/24440874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24440874 | http://www.w3.org/2000/01/rdf-schema#comment | "The forkhead box A transcription factors, FOXA1 and FOXA2, function as pioneer factors to open condensed chromatin and facilitate binding of other proteins. We showed previously that these factors are key components of a transcriptional network that drives enhancer function at the cystic fibrosis transmembrane conductance regulator (CFTR) locus in intestinal epithelial cells. The CFTR promoter apparently lacks tissue-specific regulatory elements and expression of the gene is controlled by multiple cis-acting elements, which coordinate gene expression in different cell types. Here we show that concurrent depletion of FOXA1 and FOXA2 represses CFTR expression and alters the three-dimensional architecture of the active locus by diminishing interactions between the promoter and intronic cis-acting elements. Reduction of FOXA1/A2 also modifies the enrichment profile of the active enhancer marks H3K27ac and H3K4me2 across the CFTR locus and alters chromatin accessibility at individual cis-elements. Moreover, loss of FOXA1/A2 suppresses the recruitment of other members of the transcriptional network including HNF1 and CDX2, to multiple cis-elements. These data reveal a complex molecular mechanism underlying the role of FOXA1/A2 in achieving high levels of CFTR expression in intestinal epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/24440874 | http://purl.org/dc/terms/identifier | "doi:10.4161/epi.27696"xsd:string |
| http://purl.uniprot.org/citations/24440874 | http://purl.uniprot.org/core/author | "Harris A."xsd:string |
| http://purl.uniprot.org/citations/24440874 | http://purl.uniprot.org/core/author | "Kerschner J.L."xsd:string |
| http://purl.uniprot.org/citations/24440874 | http://purl.uniprot.org/core/author | "Gosalia N."xsd:string |
| http://purl.uniprot.org/citations/24440874 | http://purl.uniprot.org/core/author | "Leir S.H."xsd:string |
| http://purl.uniprot.org/citations/24440874 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24440874 | http://purl.uniprot.org/core/name | "Epigenetics"xsd:string |
| http://purl.uniprot.org/citations/24440874 | http://purl.uniprot.org/core/pages | "557-565"xsd:string |
| http://purl.uniprot.org/citations/24440874 | http://purl.uniprot.org/core/title | "Chromatin remodeling mediated by the FOXA1/A2 transcription factors activates CFTR expression in intestinal epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/24440874 | http://purl.uniprot.org/core/volume | "9"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A0A089NFM8-mappedCitation-24440874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24440874 |
| http://purl.uniprot.org/uniprot/#_A0A089PPW6-mappedCitation-24440874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24440874 |
| http://purl.uniprot.org/uniprot/#_A0A088T1A1-mappedCitation-24440874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24440874 |
| http://purl.uniprot.org/uniprot/#_A0A096ZUB9-mappedCitation-24440874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24440874 |
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| http://purl.uniprot.org/uniprot/#_A0A096ZUB3-mappedCitation-24440874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24440874 |
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| http://purl.uniprot.org/uniprot/#_A0A1B0YU32-mappedCitation-24440874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24440874 |