DESCRIBE <http://purl.uniprot.org/citations/24444374>

Subject	Predicate	Object
http://purl.uniprot.org/citations/24444374	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24444374	http://www.w3.org/2000/01/rdf-schema#comment	" Aims Acquisition and detoxification of metal ions are vital biological processes. Given the requirement of metallochaperones in cellular copper distribution and metallation of cuproproteins, this study investigates whether the metallochaperones also deliver metal ions for transporters functioning in metal detoxification. Results Resistance to excess cadmium and copper of the yeast Saccharomyces cerevisiae, which is conferred by PCA1 and CaCRP1 metal efflux P-type ATPases, respectively, does not rely on known metallochaperones, Atx1p, Ccs1p, and Cox17p. Copper deficiency induced by the expression of CaCRP1 encoding a copper exporter occurs in the absence of Atx1p. Intriguingly, CCS1 encoding the copper chaperone for superoxide dismutase 1 (Sod1p) is necessary for cadmium resistance that is mediated by Ycf1p, a vacuolar cadmium sequestration transporter. This is attributed to Ccs1p's role in the maturation of Sod1p rather than its direct interaction with Ycf1p for cadmium transfer. Functional defect in Ycf1p associated with the absence of Sod1p as well as another antioxidant enzyme Glr1p is rescued by anaerobic growth or substitutions of specific cysteine residues of Ycf1p to alanine or serine. This further supports oxidative inactivation of Ycf1p in the absence of Ccs1p, Sod1p, or Glr1p. Innovation These results provide new insights into the mechanisms of metal metabolism, interaction among metal ions, and the roles for antioxidant systems in metal detoxification. Conclusion Copper metabolism and antioxidant enzymes maintain the function of Ycf1p for cadmium defense."xsd:string
http://purl.uniprot.org/citations/24444374	http://purl.org/dc/terms/identifier	"doi:10.1089/ars.2013.5436"xsd:string
http://purl.uniprot.org/citations/24444374	http://purl.uniprot.org/core/author	"Kim H."xsd:string
http://purl.uniprot.org/citations/24444374	http://purl.uniprot.org/core/author	"Lee J."xsd:string
http://purl.uniprot.org/citations/24444374	http://purl.uniprot.org/core/author	"Wei W."xsd:string
http://purl.uniprot.org/citations/24444374	http://purl.uniprot.org/core/author	"Wu X."xsd:string
http://purl.uniprot.org/citations/24444374	http://purl.uniprot.org/core/author	"Seravalli J."xsd:string
http://purl.uniprot.org/citations/24444374	http://purl.uniprot.org/core/author	"Smith N."xsd:string
http://purl.uniprot.org/citations/24444374	http://purl.uniprot.org/core/author	"Khalimonchuk O."xsd:string
http://purl.uniprot.org/citations/24444374	http://purl.uniprot.org/core/date	"2014"xsd:gYear
http://purl.uniprot.org/citations/24444374	http://purl.uniprot.org/core/name	"Antioxid Redox Signal"xsd:string
http://purl.uniprot.org/citations/24444374	http://purl.uniprot.org/core/pages	"1475-1489"xsd:string
http://purl.uniprot.org/citations/24444374	http://purl.uniprot.org/core/title	"YCF1-mediated cadmium resistance in yeast is dependent on copper metabolism and antioxidant enzymes."xsd:string
http://purl.uniprot.org/citations/24444374	http://purl.uniprot.org/core/volume	"21"xsd:string
http://purl.uniprot.org/citations/24444374	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/24444374
http://purl.uniprot.org/citations/24444374	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/24444374
http://purl.uniprot.org/uniprot/#_P39109-mappedCitation-24444374	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/24444374
http://purl.uniprot.org/uniprot/#_P40202-mappedCitation-24444374	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/24444374
http://purl.uniprot.org/uniprot/#_P41921-mappedCitation-24444374	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/24444374
http://purl.uniprot.org/uniprot/#_P38360-mappedCitation-24444374	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/24444374
http://purl.uniprot.org/uniprot/#_Q03835-mappedCitation-24444374	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/24444374
http://purl.uniprot.org/uniprot/#_P38013-mappedCitation-24444374	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/24444374
http://purl.uniprot.org/uniprot/#_Q08220-mappedCitation-24444374	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/24444374
http://purl.uniprot.org/uniprot/#_P11412-mappedCitation-24444374	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/24444374