| http://purl.uniprot.org/citations/24446161 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24446161 | http://www.w3.org/2000/01/rdf-schema#comment | "The rat enhancer of split- and hairy-related protein-1 (SHARP-1) is a basic helix-loop-helix transcription factor. An issue of whether SHARP-1 is an insulin-inducible transcription factor was examined. Insulin rapidly increased the level of SHARP-1 mRNA both in vivo and in vitro. Then, signaling pathways involved with the increase of SHARP-1 mRNA by insulin were determined in H4IIE rat hepatoma cells. Pretreatments with LY294002, wortmannin, and staurosporine completely blocked the induction effect, suggesting the involvement of both phosphoinositide 3-kinase (PI 3-K) and protein kinase C (PKC) pathways. In fact, overexpression of a dominant negative form of atypical protein kinase C lambda (aPKCλ) significantly decreased the induction of the SHARP-1 mRNA. In addition, inhibitors for the small GTPase Rac or Jun N-terminal kinase (JNK) also blocked the induction of SHARP-1 mRNA by insulin. Overexpression of a dominant negative form of Rac1 prevented the activation by insulin. Furthermore, actinomycin D and cycloheximide completely blocked the induction of SHARP-1 mRNA by insulin. Finally, when a SHARP-1 expression plasmid was transiently transfected with various reporter plasmids into H4IIE cells, the promoter activity of PEPCK reporter plasmid was specifically decreased. Thus, we conclude that insulin induces the SHARP-1 gene expression at the transcription level via a both PI 3-K/aPKCλ/JNK- and a PI 3-K/Rac/JNK-signaling pathway; protein synthesis is required for this induction; and that SHARP-1 is a potential repressor of the PEPCK gene expression."xsd:string |
| http://purl.uniprot.org/citations/24446161 | http://purl.org/dc/terms/identifier | "doi:10.1055/s-0033-1363981"xsd:string |
| http://purl.uniprot.org/citations/24446161 | http://purl.uniprot.org/core/author | "Asano K."xsd:string |
| http://purl.uniprot.org/citations/24446161 | http://purl.uniprot.org/core/author | "Tanaka T."xsd:string |
| http://purl.uniprot.org/citations/24446161 | http://purl.uniprot.org/core/author | "Yamamoto T."xsd:string |
| http://purl.uniprot.org/citations/24446161 | http://purl.uniprot.org/core/author | "Tomita K."xsd:string |
| http://purl.uniprot.org/citations/24446161 | http://purl.uniprot.org/core/author | "Ueno H."xsd:string |
| http://purl.uniprot.org/citations/24446161 | http://purl.uniprot.org/core/author | "Takagi K."xsd:string |
| http://purl.uniprot.org/citations/24446161 | http://purl.uniprot.org/core/author | "Yamada K."xsd:string |
| http://purl.uniprot.org/citations/24446161 | http://purl.uniprot.org/core/author | "Ono M."xsd:string |
| http://purl.uniprot.org/citations/24446161 | http://purl.uniprot.org/core/author | "Komatsu Y."xsd:string |
| http://purl.uniprot.org/citations/24446161 | http://purl.uniprot.org/core/author | "Noguchi T."xsd:string |
| http://purl.uniprot.org/citations/24446161 | http://purl.uniprot.org/core/author | "Ogawa W."xsd:string |
| http://purl.uniprot.org/citations/24446161 | http://purl.uniprot.org/core/author | "Haneishi A."xsd:string |
| http://purl.uniprot.org/citations/24446161 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24446161 | http://purl.uniprot.org/core/name | "Horm Metab Res"xsd:string |
| http://purl.uniprot.org/citations/24446161 | http://purl.uniprot.org/core/pages | "397-403"xsd:string |
| http://purl.uniprot.org/citations/24446161 | http://purl.uniprot.org/core/title | "Insulin stimulates the expression of the SHARP-1 gene via multiple signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/24446161 | http://purl.uniprot.org/core/volume | "46"xsd:string |
| http://purl.uniprot.org/citations/24446161 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24446161 |
| http://purl.uniprot.org/citations/24446161 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24446161 |
| http://purl.uniprot.org/uniprot/#_A0A9E9AQX1-mappedCitation-24446161 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24446161 |
| http://purl.uniprot.org/uniprot/#_A6XGL2-mappedCitation-24446161 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24446161 |
| http://purl.uniprot.org/uniprot/#_F6MZK5-mappedCitation-24446161 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24446161 |