| http://purl.uniprot.org/citations/24446484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24446484 | http://www.w3.org/2000/01/rdf-schema#comment | "Cadherins and associated catenins provide an important structural interface between neighboring cells, the actin cytoskeleton, and intracellular signaling pathways in a variety of cell types throughout the Metazoa. However, the full inventory of the proteins and pathways required for cadherin-mediated adhesion has not been established. To this end, we completed a genome-wide (~14,000 genes) ribonucleic acid interference (RNAi) screen that targeted Ca(2+)-dependent adhesion in DE-cadherin-expressing Drosophila melanogaster S2 cells in suspension culture. This novel screen eliminated Ca(2+)-independent cell-cell adhesion, integrin-based adhesion, cell spreading, and cell migration. We identified 17 interconnected regulatory hubs, based on protein functions and protein-protein interactions that regulate the levels of the core cadherin-catenin complex and coordinate cadherin-mediated cell-cell adhesion. Representative proteins from these hubs were analyzed further in Drosophila oogenesis, using targeted germline RNAi, and adhesion was analyzed in Madin-Darby canine kidney mammalian epithelial cell-cell adhesion. These experiments reveal roles for a diversity of cellular pathways that are required for cadherin function in Metazoa, including cytoskeleton organization, cell-substrate interactions, and nuclear and cytoplasmic signaling."xsd:string |
| http://purl.uniprot.org/citations/24446484 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201306082"xsd:string |
| http://purl.uniprot.org/citations/24446484 | http://purl.uniprot.org/core/author | "Simon M.A."xsd:string |
| http://purl.uniprot.org/citations/24446484 | http://purl.uniprot.org/core/author | "Vale R.D."xsd:string |
| http://purl.uniprot.org/citations/24446484 | http://purl.uniprot.org/core/author | "Nelson W.J."xsd:string |
| http://purl.uniprot.org/citations/24446484 | http://purl.uniprot.org/core/author | "Toret C.P."xsd:string |
| http://purl.uniprot.org/citations/24446484 | http://purl.uniprot.org/core/author | "D'Ambrosio M.V."xsd:string |
| http://purl.uniprot.org/citations/24446484 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24446484 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/24446484 | http://purl.uniprot.org/core/pages | "265-279"xsd:string |
| http://purl.uniprot.org/citations/24446484 | http://purl.uniprot.org/core/title | "A genome-wide screen identifies conserved protein hubs required for cadherin-mediated cell-cell adhesion."xsd:string |
| http://purl.uniprot.org/citations/24446484 | http://purl.uniprot.org/core/volume | "204"xsd:string |
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