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http://purl.uniprot.org/citations/24446656http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24446656http://www.w3.org/2000/01/rdf-schema#comment"

Context

Food ingestion decreases bone resorption, and glucose-dependent insulinotropic polypeptide (GIP) may mediate this effect. Mice overexpressing GIP have increased osteoblast activity and are rescued from age-related bone loss, whereas GIPR knockout mice have decreased cortical bone mass and compromised bone quality. Carriers of the functional variant GIPR Glu354Gln (rs1800437) have higher plasma glucose 2 hours after glucose ingestion, suggesting that the variant encoding GIPR 354Gln decreases the effect of GIP.

Objective

The objective of the study was to investigate the effect of GIPR Glu354Gln on bone mineral density (BMD) and fracture risk.

Design

This was a prospective, comprehensive, cohort study (number NCT00252408).

Participants

A total of 1686 perimenopausal women were included.

Main outcome measures

Dual-energy X-ray absorptiometry was performed at baseline and after 10 years. Incident fractures were recorded during the follow-up and were obtained from the Danish National Patient Registry, giving a total follow-up time of a minimum 16 years.

Results

After 10 years, women with the minor frequency C allele of rs1800437 (354Gln) had significantly lower BMD at the femoral neck compared with carriers of the major G-allele (CC: 0.755 ± 0.015 g/cm(2) vs CG: 747 ± 0.005 g/cm(2); GG: 0.766 ± 0.004 g/cm(2), P < .001). Correspondingly, total hip BMD was significantly lower among C allele carriers (CC: 0.881 ± 0.016 g/cm(2); CG: 0.884 ± 0.005 g/cm(2); and GG: 0.906 ± 0.004 g/cm(2), P < .001). Finally, women homozygous for the variant C allele had an increased risk (hazard ratio 1.6, confidence interval 1.0-2.6, P < .05) of nonvertebral fractures.

Conclusion

This study demonstrates an association between a functional GIPR polymorphism Glu354Gln (rs1800437) and BMD and fracture risk. These findings further establish GIP to be involved in the regulation of bone density."xsd:string
http://purl.uniprot.org/citations/24446656http://purl.org/dc/terms/identifier"doi:10.1210/jc.2013-3766"xsd:string
http://purl.uniprot.org/citations/24446656http://purl.uniprot.org/core/author"Hansen T."xsd:string
http://purl.uniprot.org/citations/24446656http://purl.uniprot.org/core/author"Pedersen O."xsd:string
http://purl.uniprot.org/citations/24446656http://purl.uniprot.org/core/author"Jensen J.B."xsd:string
http://purl.uniprot.org/citations/24446656http://purl.uniprot.org/core/author"Holst J.J."xsd:string
http://purl.uniprot.org/citations/24446656http://purl.uniprot.org/core/author"Langdahl B.L."xsd:string
http://purl.uniprot.org/citations/24446656http://purl.uniprot.org/core/author"Torekov S.S."xsd:string
http://purl.uniprot.org/citations/24446656http://purl.uniprot.org/core/author"Harslof T."xsd:string
http://purl.uniprot.org/citations/24446656http://purl.uniprot.org/core/author"Rejnmark L."xsd:string
http://purl.uniprot.org/citations/24446656http://purl.uniprot.org/core/author"Eiken P."xsd:string
http://purl.uniprot.org/citations/24446656http://purl.uniprot.org/core/author"Herman A.P."xsd:string
http://purl.uniprot.org/citations/24446656http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/24446656http://purl.uniprot.org/core/name"J Clin Endocrinol Metab"xsd:string
http://purl.uniprot.org/citations/24446656http://purl.uniprot.org/core/pages"E729-33"xsd:string
http://purl.uniprot.org/citations/24446656http://purl.uniprot.org/core/title"A functional amino acid substitution in the glucose-dependent insulinotropic polypeptide receptor (GIPR) gene is associated with lower bone mineral density and increased fracture risk."xsd:string
http://purl.uniprot.org/citations/24446656http://purl.uniprot.org/core/volume"99"xsd:string
http://purl.uniprot.org/citations/24446656http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/24446656
http://purl.uniprot.org/citations/24446656http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/24446656
http://purl.uniprot.org/uniprot/#_Q4VBP1-mappedCitation-24446656http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24446656
http://purl.uniprot.org/uniprot/#_P48546-mappedCitation-24446656http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24446656
http://purl.uniprot.org/uniprot/P48546http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/24446656
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