| http://purl.uniprot.org/citations/24447516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24447516 | http://www.w3.org/2000/01/rdf-schema#comment | "To exert its analgesic action, paracetamol requires complex metabolism to produce a brain-specific lipoamino acid compound, AM404, which targets central transient receptor potential vanilloid receptors (TRPV1). Lipoamino acids are also known to induce analgesia through T-type calcium-channel inhibition (Ca(v)3.2). In this study we show that the antinociceptive effect of paracetamol in mice is lost when supraspinal Ca(v)3.2 channels are inhibited. Therefore, we hypothesized a relationship between supraspinal Ca(v)3.2 and TRPV1, via AM404, which mediates the analgesic effect of paracetamol. AM404 is able to activate TRPV1 and weakly inhibits Ca(v)3.2. Interestingly, activation of TRPV1 induces a strong inhibition of Ca(v)3.2 current. Supporting this, intracerebroventricular administration of AM404 or capsaicin produces antinociception that is lost in Ca(v)3.2(-/-) mice. Our study, for the first time, (1) provides a molecular mechanism for the supraspinal antinociceptive effect of paracetamol; (2) identifies the relationship between TRPV1 and the Ca(v)3.2 channel; and (3) suggests supraspinal Ca(v)3.2 inhibition as a potential pharmacological strategy to alleviate pain."xsd:string |
| http://purl.uniprot.org/citations/24447516 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.pain.2014.01.015"xsd:string |
| http://purl.uniprot.org/citations/24447516 | http://purl.uniprot.org/core/author | "Mallet C."xsd:string |
| http://purl.uniprot.org/citations/24447516 | http://purl.uniprot.org/core/author | "Alloui A."xsd:string |
| http://purl.uniprot.org/citations/24447516 | http://purl.uniprot.org/core/author | "Eschalier A."xsd:string |
| http://purl.uniprot.org/citations/24447516 | http://purl.uniprot.org/core/author | "Bourinet E."xsd:string |
| http://purl.uniprot.org/citations/24447516 | http://purl.uniprot.org/core/author | "Chemin J."xsd:string |
| http://purl.uniprot.org/citations/24447516 | http://purl.uniprot.org/core/author | "Voets T."xsd:string |
| http://purl.uniprot.org/citations/24447516 | http://purl.uniprot.org/core/author | "Boudes M."xsd:string |
| http://purl.uniprot.org/citations/24447516 | http://purl.uniprot.org/core/author | "Francois A."xsd:string |
| http://purl.uniprot.org/citations/24447516 | http://purl.uniprot.org/core/author | "Kerckhove N."xsd:string |
| http://purl.uniprot.org/citations/24447516 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24447516 | http://purl.uniprot.org/core/name | "Pain"xsd:string |
| http://purl.uniprot.org/citations/24447516 | http://purl.uniprot.org/core/pages | "764-772"xsd:string |
| http://purl.uniprot.org/citations/24447516 | http://purl.uniprot.org/core/title | "Ca(v)3.2 calcium channels: the key protagonist in the supraspinal effect of paracetamol."xsd:string |
| http://purl.uniprot.org/citations/24447516 | http://purl.uniprot.org/core/volume | "155"xsd:string |
| http://purl.uniprot.org/citations/24447516 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24447516 |
| http://purl.uniprot.org/citations/24447516 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24447516 |
| http://purl.uniprot.org/uniprot/#_E9Q6P9-mappedCitation-24447516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24447516 |
| http://purl.uniprot.org/uniprot/#_O88427-mappedCitation-24447516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24447516 |
| http://purl.uniprot.org/uniprot/#_Q6PE92-mappedCitation-24447516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24447516 |
| http://purl.uniprot.org/uniprot/#_Q3UX23-mappedCitation-24447516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24447516 |
| http://purl.uniprot.org/uniprot/#_Q99P43-mappedCitation-24447516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24447516 |
| http://purl.uniprot.org/uniprot/#_Q9JJ85-mappedCitation-24447516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24447516 |