| http://purl.uniprot.org/citations/24453324 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24453324 | http://www.w3.org/2000/01/rdf-schema#comment | "Plp1 gene expression occurs very early in development, well before the onset of myelination, creating a conundrum with regard to the function of myelin proteolipid protein (PLP), one of the major proteins in compact myelin. Using PLP-EGFP mice to investigate Plp1 promoter activity, we found that, at very early time points, PLP-EGFP was expressed in Sox2+ undifferentiated precursors in the spinal cord ventricular zone (VZ), as well as in the progenitors of both neuronal and glial lineages. As development progressed, most PLP-EGFP-expressing cells gave rise to oligodendrocyte progenitor cells (OPCs). The expression of PLP-EGFP in the spinal cord was quite dynamic during development. PLP-EGFP was highly expressed as cells delaminated from the VZ. Expression was downregulated as cells moved laterally through the cord, and then robustly upregulated as OPCs differentiated into mature myelinating oligodendrocytes. The presence of PLP-EGFP expression in OPCs raises the question of its role in this migratory population. We crossed PLP-EGFP reporter mice into a Plp1-null background to investigate the role of PLP in early OPC development. In the absence of PLP, normal numbers of OPCs were generated and their distribution throughout the spinal cord was unaffected. However, the orientation and length of OPC processes during migration was abnormal in Plp1-null mice, suggesting that PLP plays a role either in the structural integrity of OPC processes or in their response to extracellular cues that orient process outgrowth."xsd:string |
| http://purl.uniprot.org/citations/24453324 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.2477-13.2014"xsd:string |
| http://purl.uniprot.org/citations/24453324 | http://purl.uniprot.org/core/author | "Macklin W.B."xsd:string |
| http://purl.uniprot.org/citations/24453324 | http://purl.uniprot.org/core/author | "Saul K.E."xsd:string |
| http://purl.uniprot.org/citations/24453324 | http://purl.uniprot.org/core/author | "Culp C.M."xsd:string |
| http://purl.uniprot.org/citations/24453324 | http://purl.uniprot.org/core/author | "Harlow D.E."xsd:string |
| http://purl.uniprot.org/citations/24453324 | http://purl.uniprot.org/core/author | "Vesely E.M."xsd:string |
| http://purl.uniprot.org/citations/24453324 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24453324 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/24453324 | http://purl.uniprot.org/core/pages | "1333-1343"xsd:string |
| http://purl.uniprot.org/citations/24453324 | http://purl.uniprot.org/core/title | "Expression of proteolipid protein gene in spinal cord stem cells and early oligodendrocyte progenitor cells is dispensable for normal cell migration and myelination."xsd:string |
| http://purl.uniprot.org/citations/24453324 | http://purl.uniprot.org/core/volume | "34"xsd:string |
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